Establishment of substrates exploration of protozoan enzymes associated with invasion into host cells
| Project/Area Number |
21780263
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATO Kentaro The University of Tokyo, 大学院・農学生命科学研究科, 助教 (30401178)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 原虫 / 基質 / 酵素 / 宿主細胞侵入 / プロテインキナーゼ |
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| Research Abstract |
We have got some results that protozoa enzymes including protein kinases take parts in the important signal transductions for parasites to transfer from a stage to the next stage by analyzing the substrates and functions of enzymes relating with calcium signaling in their complicated life cycles. These results lead to the new anti-protozoan drug developments to block the protozoa-specific life cycle by inhibiting the functions of the important protozoan enzymes in the stage transfer.
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Report
(3 results)
Research Products
(35 results)
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[Journal Article] Identification of Toxonlasma cAMP dependent protein kinase and its role in the tachyzoite growth.2011
Author(s)
Kurokawa H, Kato K (corresponding author), Iwanaga T, Sugi T, Sudo A, Kobayashi K, Gong H, Takemae H, Recuenco FC, Horimoto T, Akashi H.
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Journal Title
Related Report
Peer Reviewed
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