| Project/Area Number |
21780277
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied veterinary science
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| Research Institution | Nagasaki University |
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Principal Investigator |
YAMANAKA Hitoki Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (30533921)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 人獣共通感染症 / プリオン / リコンビナントプリオン蛋白 / ワクチン / 免疫学的治療法 |
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| Research Abstract |
Prion diseases in humans and animals are fatal neurodegenerative disorders and no effective therapeutic methods for prion diseases were developed. In this study, to acquire the basic information for development of prion vaccine and immunotherapeutic methods, recombinant proteinase-sensitive (rPrP-sen) and -resistant prion protein (rPrP-res), were prepared by the real-time quaking-induced conversion method. The immunoresponses were evaluated by immunization to mice with these materials. The results from this study suggest that these materials, rPrP-sen and -res, are useful tools as a newly immunogen for development of prion vaccines and therapeutic methods.
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