| Project/Area Number |
21790008
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
KOGURE Noriyuki Chiba University, 大学院・薬学研究院, 助教 (80396689)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アルカロイド / 不斉全合成 / AChエステラーゼ / リコポジウム / ヒガンバナ / アセチルコリンエステラーゼ / 構造決定 / Lycoposerramine |
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| Research Abstract |
In recent years, by the rapid increase of the elderly person, development of effective and safe drugs for memory improvement becomes the urgent business. The inhibition of acetylcholine esterase (AChE) brings increase of acetylcholine in the brain by controlling a function of and can improve defects of memory.
In this study, it was aimed for the search of alkaloids (base ingredient) which had AChE inhibitory activity by separation from Lycopodium and Amaryllidaceae plants, chemical synthesis of natural alkaloids. As a result, we succeeded in the isolation of many new alkaloids and achieved the total syntheses of several kinds of natural alkaloids.
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