Development of a sensitive method for catecholamines using on-chip liquid chromatography
| Project/Area Number |
21790033
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TSUNODA Makoto 東京大学, 大学院・薬学系研究科, 講師 (10323453)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 分析化学 / クロマトグラフィー / マイクロ化学チップ / 生体分子 / マイクロ・ナノデバイス |
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| Research Abstract |
The separation efficiency of a pillar array column under pressure-driven liquid chromatography conditions can be improved using a separation channel with low-dispersion turns. The pillar array column was fabricated by reactive ion etching of a silicon substrate. Two coumarin dyes were well resolved under reversed-phase conditions with a maximum theoretical plate number of 8000. Successful separation of the fluorescent derivatives of six amino acids was achieved in 140 s.
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Report
(3 results)
Research Products
(7 results)
