Investigation into mechanism of inhibitive cholesterol absorption by plant sterols and the novel method
| Project/Area Number |
21790043
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Showa Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 物理化学 / 脂質 / 食品 / コロイド |
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| Research Abstract |
The mechanism of cholesterol lowering by the addition of several kinds of plant sterols/sterols was investigated in model intestinal solution. Slight differences in the molecular structures of a category of sterol/stanol species affect the solubility of cholesterol in a model intestinal solution. The results of competitive solubilization revealed that cholestanol has the largest cholesterol-lowering effect, decreasing cholesterol solubility to 35% of that in a single solubilizate system. The cholesterol-lowering effect increase in the order of<brassicasterol<stigmasterol<fucosterol<campesterol<sitostanol<sitosterol<cholestanol.
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Report
(4 results)
Research Products
(12 results)
