The roles of the liver-derived endocrine factor,Fgf21, in the white adipose tissue

• Project/Area Number: 21790071
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Kobe Pharmaceutical University
• Principal Investigator: KONISHI Morichika Kobe Pharmaceutical University, 薬学部, 准教授 (00322165)
• Co-Investigator(Renkei-kenkyūsha): ITOH Nobuyuki 京都大学, 薬学研究科・遺伝子薬学分野 (10110610)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: FGF / 白色脂肪細胞 / エネルギー代謝 / 肥満症 / 白色脂肪組織 / Fgf / ケトン食 / インスリン感受性 / Lp1 / 脂肪組織 / 脂肪分解 / 絶食 / 脂質代謝

Research Abstract

The pharmacological effects suggest that liver-derived Fgf21 physiologically regulates the function of white adipose tissue and systemic energy metabolism. To elucidate the physiological roles of Fgf21, we analyzed Fgf21 knockout mice generated by targeted disruption under several conditions including fasting. Our results indicate that Fgf21 regulates lipolysis in white adipose tissue and systemic insulin sensitivity in response to the metabolic state.

Research Products

• [Journal Article] FGF21 as an Endocrine Regulator in Lipid Metabolism : From MolecularEvolution to Physiology and Pathophysiology. (2011)
  • Author(s): Murata Y, Konishi M, Itoh
  • Journal Title: N.J.Nutr.Metab. Pages: 981351-981351
• [Journal Article] FGF21 as an Endocrine Regulator in Lipid Metabolism : From Molecular Evolution to Physiology and Pathophysiology. (2011)
  • Author(s): Murata Y, Konishi M, Itoh N.
  • Journal Title: Journal of Nutrition and Metabolism Volume: 981351
  • Peer Reviewed
• [Journal Article] FGF21 is dispensable for hypothermia induced by fasting in mice. (2010)
  • Author(s): Oishi K., Sakamoto K., Konishi M., Murata Y., Itoh N., Sei H.
  • Journal Title: Neuro.Endocrinol.Lett. 31 Pages: 198-202
• [Journal Article] A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer. (2010)
  • Author(s): Masuda Y., Ito K., Konishi M., Nanba H.
  • Journal Title: Cancer Immun.Immunother. 59 Pages: 1531-1541
• [Journal Article] FGF21 is dispensable for hypothermia induced by fasting in mice. (2010)
  • Author(s): Oishi K, Sakamoto K, Konishi M, Murata Y, Itoh N, Sei H.
  • Journal Title: Neuro-endocrinology letters Volume: 31 Pages: 198-202
  • Peer Reviewed
• [Journal Article] A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer. (2010)
  • Author(s): Masuda Y, Ito K, Konishi M, Nanba H.
  • Journal Title: Cancer Immunology, Immunotherapy Volume: 59 Pages: 1531-1541
  • Peer Reviewed
• [Journal Article] Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling (2009)
  • Author(s): Miyake A., Takahashi Y., Miwa H., Shimada A., Konishi M., Itoh N.
  • Journal Title: Biochem.Biophys.Res.Commun. 390 Pages: 1051-1055
  • NAID: 120001750134
• [Journal Article] A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. (2009)
  • Author(s): Miwa H., Miyake A., Kouta Y., Shimada A., Yamashita Y., Nakayama Y., Yamauchi H., Konishi M., Itoh N.
  • Journal Title: FEBS Lett. 583 Pages: 3643-3648
• [Journal Article] Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. (2009)
  • Author(s): Hotta Y., Nakamura H., Konishi M., Murata Y., Takagi H., Matsumura S., Inoue K., Fushiki T., Itoh N.
  • Journal Title: Endocrinology 150 Pages: 4625-4633
• [Journal Article] Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver (2009)
  • Author(s): Hotta Y., Nakamura H., Konishi M., Murata Y., Takagi H., Matsumura S., Inoue K., Fushiki T., Itoh N.
  • Journal Title: Endocrinology 150 Pages: 4625-4633
  • Peer Reviewed
• [Journal Article] A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family (2009)
  • Author(s): Miwa H., Miyake A., Kouta Y., Shimada A., Yamashita Y., Nakayama Y., Yamauchi H., Konishi M., Itoh N
  • Journal Title: FEBS Letter 583 Pages: 3643-3648
  • Peer Reviewed
• [Journal Article] Neucrin is a novel neural-specific secreted antagonist to canonical Wntsignaling (2009)
  • Author(s): Miyake A., Takahashi Y., Miwa H., Shimads A., Konishi M., Itoh N.
  • Journal Title: Biochemical Biophysical Research Communication 390 Pages: 1051-1055
  • NAID: 120001750134
  • Peer Reviewed
• [Presentation] 白色脂肪組織における新規分泌性タンパク質Neudesinの役割 (2010)
  • Author(s): 太田紘矢、椎野円、山上雅人、小西守周、木村郁夫、伊藤信行
  • Organizer: BMB2010
  • Year and Date: 2010-12-07
• [Presentation] 白色脂肪細胞におけるFGF21シグナルによる脂質代謝調節 (2009)
  • Author(s): 小西守周, 伊藤信行
  • Organizer: 第30回日本肥満学会学術大会
  • Year and Date: 2009-10-09
• [Book] 日本臨床社 (2010)
  • Author(s): 小西守周、伊藤信行
  • Total Pages: 5
  • Publisher: 日本臨床増刊メタボリックシンドローム(第2版)-基礎・臨床の最新知見-
• [Book] 日本臨床増刊メタボリックシンドローム(第2版)-基礎・臨床の最新知見- (2010)
  • Author(s): 小西守周、伊藤信行
  • Total Pages: 5
  • Publisher: 日本臨床社
• [Remarks] ホームページ等