Synthesis and structure activity relationship of atpenin A5 derivatives as complex II inhibitors
| Project/Area Number |
21790117
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
OHTAWA Masaki Kitasato University, 薬学部, 助教 (70453503)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 天然有機化合物 / 生理活性物質 / 構造活性相関 / 創薬化学 / 天然物 |
|---|
| Research Abstract |
Comprehensive structure activity relationship of atpenin A5 as a potent complex II inhibitor and the synthesis of atpenin A5/flutolanil chimeric inhibitors has been achieved. On the guidance of this study, we also constructed a potential basis for the discovery of atpenin A5 derivatives as novel antihelminth agents.
|
Report
(3 results)
Research Products
(6 results)
