Molecular mechanism underling inflammatory hypothesis of cerebellum damage caused by methylmercury
| Project/Area Number |
21790134
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Tokyo University of Science (2010)
Hokuriku University (2009) |
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Principal Investigator |
HIROOKA Takashi Tokyo University of Science, 薬学部, 助教 (50397519)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | メチル水銀 / 小脳障害 / 炎症仮説 / 脳微小血管内皮細胞 / 脳微小血管周皮細胞 / ヒアルロナン / Aldose reductase / アルドース還元酵素 / 細胞膨張 / 脳微小血内皮細胞 / 浮腫仮説 |
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| Research Abstract |
We hypothesize that selective damage of methylmercury to granular cell layer in cerebellum might be due to the inflammation of tissue caused by methylmercury. In present study, we found that methylmercury stimulates the synthesis of hyaluronan and expression of aldose reductase in cultured human brain microvascular cells. Hyaluronan and aldose reductase are involved in development of inflammatory lesion. These results suggest the possibility that regulation of expression of hyaluronan and aldose reductase might be one of the molecular mechanism underling inflammation of cerebellar tissue caused by methylmercury.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Cell-density-dependent methylmercury susceptibility of cultured human brain microvascular pericytes.2010
Author(s)
Takashi Hirooka, Yasuyuki Fujiwara, Yuka Minami, Akihiko Ishii, Mio Ishigooka, Yasuhiro Shinkai, Chika Yamamoto, Akira Yasutake, Masahiko Sato, Komyo Eto, Toshiyuki Kaji.
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Journal Title
Toxicology in Vitro. 24
Pages: 835-841
Related Report
Peer Reviewed
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