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Molecular mechanism underling inflammatory hypothesis of cerebellum damage caused by methylmercury

Research Project

Project/Area Number 21790134
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Environmental pharmacy
Research InstitutionTokyo University of Science (2010)
Hokuriku University (2009)

Principal Investigator

HIROOKA Takashi  Tokyo University of Science, 薬学部, 助教 (50397519)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsメチル水銀 / 小脳障害 / 炎症仮説 / 脳微小血管内皮細胞 / 脳微小血管周皮細胞 / ヒアルロナン / Aldose reductase / アルドース還元酵素 / 細胞膨張 / 脳微小血内皮細胞 / 浮腫仮説
Research Abstract

We hypothesize that selective damage of methylmercury to granular cell layer in cerebellum might be due to the inflammation of tissue caused by methylmercury. In present study, we found that methylmercury stimulates the synthesis of hyaluronan and expression of aldose reductase in cultured human brain microvascular cells. Hyaluronan and aldose reductase are involved in development of inflammatory lesion. These results suggest the possibility that regulation of expression of hyaluronan and aldose reductase might be one of the molecular mechanism underling inflammation of cerebellar tissue caused by methylmercury.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (22 results)

All 2011 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (16 results) Remarks (1 results)

  • [Journal Article] Resistance of human brain microvascular endothelial cells in culture to methylmercury: cell-density-dependent defense mechanisms.2010

    • Author(s)
      Takashi Hirooka, Yasuyuki Fujiwara, Yasuhiro Shinkai, Chika Yamamoto, Akira Yasutake, Masahiko Sato, Komyo Eto, Toshiyuki Kaji.
    • Journal Title

      The Journal of Toxicological Sciences. 35

      Pages: 287-294

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell-density-dependent methylmercury susceptibility of cultured human brain microvascular pericytes.2010

    • Author(s)
      Takashi Hirooka, Yasuyuki Fujiwara, Yuka Minami, Akihiko Ishii, Mio Ishigooka, Yasuhiro Shinkai, Chika Yamamoto, Akira Yasutake, Masahiko Sato, Komyo Eto, Toshiyuki Kaji.
    • Journal Title

      Toxicology in Vitro. 24

      Pages: 835-841

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resistance of human brain microvascular endothelial cells in culture to methylmercury : Cell-density-dependent defense mechanisms2010

    • Author(s)
      Takashi Hirooka
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 35 Pages: 287-294

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell-density-dependent methylmercury susceptibility of cultured human brain microvascular pericytes

    • Author(s)
      Takashi Hirooka
    • Journal Title

      Toxicology in Vitro (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resistance of human brain microvascular endothelial cells in culture to methylmercury : Cell-density-dependent defense mechanisms

    • Author(s)
      Takashi Hirooka
    • Journal Title

      The Journal of Toxicological Sciences (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 傷害ヒト脳微小血管内皮細胞層の修復に対するメチル水銀の阻害作用は低酸素下において増強される2011

    • Author(s)
      廣岡孝志
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 傷害ヒト脳微小血管内皮細胞層の修復に対するメチル水銀の阻害作用は低酸素下において増強される2011

    • Author(s)
      廣岡孝志
    • Organizer
      日本薬学会 第131年会
    • Place of Presentation
      静岡 ツインメッセ静岡
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] The microvascular cells are a target of methylmercury toxicity, NIMD FORUM 2011 Methylmercury toxicology: Up-to-date Research on Mechanisms.2011

    • Author(s)
      廣岡孝志
    • Organizer
      Toxicology and Pathology.
    • Place of Presentation
      水俣市
    • Year and Date
      2011-01-27
    • Related Report
      2010 Final Research Report
  • [Presentation] The microvascular cells are a target of methylmercury toxicity2011

    • Author(s)
      廣岡孝志
    • Organizer
      NIMD FORUM 2011 Methylmercury toacology : Up-to-da-te Research on Mechanisms, Toxicology and Pathology
    • Place of Presentation
      国立水俣病情報センター
    • Year and Date
      2011-01-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト脳微小血管内皮細胞層に対するメチル水銀の毒性発現は低酸素環境下において増強される2010

    • Author(s)
      廣岡孝志
    • Organizer
      フォーラム2010衛生薬学・環境トキシコロジー
    • Place of Presentation
      東京
    • Year and Date
      2010-09-10
    • Related Report
      2010 Final Research Report
  • [Presentation] メチル水銀の血管毒性に関する研究2010

    • Author(s)
      廣岡孝志
    • Organizer
      フォーラム2010衛生薬学・環境トキシコロジー(平成22年度日本薬学会環境.衛生部会賞受賞講演)
    • Place of Presentation
      東京
    • Year and Date
      2010-09-10
    • Related Report
      2010 Final Research Report
  • [Presentation] メチル水銀の血管毒性に関する研究2010

    • Author(s)
      廣岡孝志
    • Organizer
      フォーラム2010衛生薬学・環境トキシコロジー
    • Place of Presentation
      星薬科大学
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト脳微小血管内皮細胞層に対するメチル水銀の毒性発現は低酸素環境下において増強される2010

    • Author(s)
      廣岡孝志
    • Organizer
      フォーラム2010衛生薬学・環境トキシコロジー
    • Place of Presentation
      星薬科大学
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] メチル水銀はヒト脳微小血管内皮および周皮細胞のヒアルロナン合成を誘導する2010

    • Author(s)
      廣岡孝志
    • Organizer
      第37回日本トキシコロジー学会学術年会
    • Place of Presentation
      沖縄
    • Year and Date
      2010-06-18
    • Related Report
      2010 Final Research Report
  • [Presentation] メチル水銀はヒト脳微小血管内皮および周皮細胞のビアルロナン合成を誘導する2010

    • Author(s)
      廣岡孝志
    • Organizer
      第37回 日本トキシコロジー学会 学術年会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] メチル水銀は脳浮腫形成に関与する脳血管組織のVEGFシステムを活性化する2010

    • Author(s)
      廣岡孝志
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] メチル水銀は脳浮腫形成に関与する脳血管組織のVEGFシステムを活性化する2010

    • Author(s)
      廣岡孝志
    • Organizer
      日本薬学会 第130年会
    • Place of Presentation
      桃太郎アリーナ(岡山県)
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] メチル水銀は培養ヒト脳微小血管内皮細胞および周皮細胞のヒアルロナン合成を促進する2009

    • Author(s)
      廣岡孝志
    • Organizer
      フォーラム2009衛生薬学・環境トキシコロジー
    • Place of Presentation
      沖縄
    • Year and Date
      2009-11-06
    • Related Report
      2010 Final Research Report
  • [Presentation] メチル水銀は培養ヒト脳微小血管内皮細胞および周皮細胞のヒアルロナン合成を促進する2009

    • Author(s)
      廣岡孝志
    • Organizer
      フォーラム2009 衛生薬学・環境トキシコロジー
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県)
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] メチル水銀による小脳障害のメカニズムに関する新しい仮説2009

    • Author(s)
      廣岡孝志
    • Organizer
      第36回日本トキシコロジー学会学術年会(優秀研究発表賞受賞)
    • Place of Presentation
      岩手県
    • Year and Date
      2009-07-07
    • Related Report
      2010 Final Research Report
  • [Presentation] メチル水銀による小脳障害のメカニズムに関する新しい仮説2009

    • Author(s)
      廣岡孝志
    • Organizer
      第36回 日本トキシコロジー学会 学術年会
    • Place of Presentation
      アイーナ(岩手県)
    • Year and Date
      2009-07-07
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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