Molecular analysis of the alteration in renal excretion of drugs by liver ischemia-reperfusion injury
| Project/Area Number |
21790166
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Kinjo Gakuin University |
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Principal Investigator |
IKEMURA Kenji Kinjo Gakuin University, 薬学部, 助教 (70513935)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 肝虚血再灌流障害 / 酸化ストレス / 薬物トランスポータ / トランスポータ / 薬物体内動態 / OCT2 / MATE1 / 肝移植 / 薬物代謝酵素 |
|---|
| Research Abstract |
The effect of liver I/R injury on the renal excretion of drugs was investigated to establish the individual drug therapy after liver transplantation. This study suggested that the systemic clearance of cimetidine was decreased after liver I/R, and that this alternation is attributable to the decreased renal excretion mediated by rOCT2 and rMATE1 in the kidney. The present findings provide useful information for our understanding of renal disposition of cationic drugs in liver I/R injury.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide.2010
Author(s)
Hideki Mizutani, Yusuke Hiraku, Saeko Tada-Oikawa, Mariko Murata, Kenji Ikemura, Takuya Iwamoto, Yoshiyuki Kagawa, Masahiro Okuda, Shosuke Kawanishi
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Journal Title
Cancer Science
Volume: 101(10)
Pages: 2214-2219
NAID
Related Report
Peer Reviewed
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[Book] 腫瘍薬学2010
Author(s)
川西正祐、大井一弥、中瀬一則、水谷秀樹、池村健治
Total Pages
573
Publisher
南山堂
Related Report
