Role of galectin in homeostasis and mucosal immunity in the female genital system

• Project/Area Number: 21790174
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Hokkaido University
• Principal Investigator: KOBAYASHI Junko Hokkaido University, 大学院・医学研究科, 助教 (70447043)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: レクチン / ガレクチン / 雌性生殖器 / プロジェステロン / エストロジェン / 子宮 / 膣 / 卵管 / 粘膜免疫

Research Abstract

This study revealed the cell- and stage-specific expression of β-galactoside-binding lectin, galectin, in the female genital system of mice. The expression of galectin is affected by steroids such as estrogen and progesterone and may play an important role in homeostasis and mucosal immunity in the female genital system.

Research Products

• [Journal Article] Cellular expression of monocarboxylate transporters in the female reproductive organ of mice : implications for the genital lactate shuttle. (2011)
  • Author(s): Kuchiiwa T, Nio-Kobayashi J, Takahashi-Iwanaga H, Yajima T, Iwanaga T.
  • Journal Title: Histochem Cell Biol 135 Pages: 351-360
• [Journal Article] Cellular expression of monocarboxylate transporters in the female reproductive organ of mice : implications for the genital lactate shuttle. (2011)
  • Author(s): Kuchiiwa, et al.
  • Journal Title: Histochemistry and Cell Biology Volume: 135 Pages: 351-360
  • Peer Reviewed
• [Journal Article] The cellular expression of SMCT2 and its comparison with other transporters for monocarboxylates in the mouse digestive tract. (2010)
  • Author(s): Teramae H, Nio-Kobayashi J, Takahashi-Iwanaga H, Yajima T, Iwanaga T.
  • Journal Title: Biomed Res 31 Pages: 239-249
• [Journal Article] Differential cellular localization of galectin-1 and galectin-3 in the regressing corpus luteum of mice and their possible contribution to luteal cell elimination. (2010)
  • Author(s): Nio-Kobayashi J, Iwanaga T.
  • Journal Title: J Histochem Cytochem 58 Pages: 741-749
• [Journal Article] Changes in plasma gonadotropins, inhibin and testosterone concentrations and testicular gonadotropin receptor mRNA expression during testicular active, regressive and recrudescent phase in the captive Japanese black bear (Ursus thibetanus japonicas). (2010)
  • Author(s): Iibuchi R, Kamine A, Shimozuru M, Nio-Kobayashi J, Watanabe G, Taya K, Tsubota T
  • Journal Title: Jpn J Vet Res 57 Pages: 185-196
• [Journal Article] Localization of five steroidogenic enzyme mRNAs in Japanese black bear (Ursus thibetanus japonicas) testes during the mating season by in situ hybridization. (2010)
  • Author(s): Iibuchi R, Shimozuru M, Kamine A, Nio-Kobayashi J, Iwanaga T, Tsubota T.
  • Journal Title: J Reprod Dev 56 Pages: 236-242
• [Journal Article] Cellular expression of the monocarboxylate transporter (MCT) family in the placenta of mice. (2010)
  • Author(s): Nagai A, Takebe K, Nio-Kobayashi J, Takahashi-Iwanaga H, Iwanaga T.
  • Journal Title: Placenta 31 Pages: 126-133
• [Journal Article] Differential cellular localization of galectin-1 and galectin-3 in the regressing corpus luteum of mice and their possible contribution to luteal cell elimination (2010)
  • Author(s): Junko NIO-KOBAYASHI, et al.
  • Journal Title: Journal of Histochemistry & Cytochemistry Volume: 58 Pages: 741-749
  • Peer Reviewed
• [Journal Article] The cellular expression of SMCT2 and its comparison with other transporters for monocarboxylates in the mouse digestive tract. (2010)
  • Author(s): Teramae, et al.
  • Journal Title: Biomedical Research Volume: 31 Pages: 239-249
  • Peer Reviewed
• [Journal Article] High incidence of metabolically active brown adipose tissue in healthy adult humans : effects of cold exposure and adiposity. (2009)
  • Author(s): Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, Iwanaga T, Miyagawa M, Kameya T, Nakada K, Kawai Y, Tsujisaki M.
  • Journal Title: Diabetes 58 Pages: 1526-1531
• [Journal Article] Cellular expression of a monocarboxylate transporter (MCT1) in the mammary gland and sebaceous gland of mice. (2009)
  • Author(s): Takebe K, Nio-Kobayashi J, Takahashi-Iwanaga H, Yajima T, Iwanaga T.
  • Journal Title: Histochem Cell Biol 131 Pages: 401-409
• [Journal Article] Immunohistochemical localization of six galectin subtypes in the mouse digestive tract. (2009)
  • Author(s): Nio-Kobayashi J, Takahashi-Iwanaga H, Iwanaga T.
  • Journal Title: J Histochem Cytochem 57 Pages: 41-50
• [Journal Article] Immunohistochemical localization of six galectin subtypes in the mouse digestive tract (2009)
  • Author(s): Junko NIO-KOBAYASHI, et al.
  • Journal Title: Journal of Histochemistry & Cytochemistry 57 Pages: 41-50
  • Peer Reviewed
• [Journal Article] Differential cellular localization of galectin-1 and galectin-3 in the regressing corpus luteum of mice and their possible contribution to luteal cell elimination
  • Author(s): Junko NIO-KOBAYASHI, et al.
  • Journal Title: Journal of Histochemistry & Cytochemistry (in press)
  • Peer Reviewed
• [Presentation] 糖鎖認識タンパク、ガレクチンの発現解析と予想される役割 (2009)
  • Author(s): 小林純子、岩永敏彦
  • Organizer: 第15回Hindgut Club Japan
  • Place of Presentation: 東京、専修大学 神田キャンパス
  • Year and Date: 2009-12-04
• [Presentation] 糖鎖認識タンパク、ガレクチンの発現解析と予想される役割 (2009)
  • Author(s): 小林純子
  • Organizer: 第15回 Hindgut Club Japan
  • Place of Presentation: 東京、専修大学 神田キャンパス
  • Year and Date: 2009-12-04
• [Presentation] マウスの子宮と膣におけるガレクチンの発現解析～ガレクチンは雌性ホルモンにより発現調節をうけるか (2009)
  • Author(s): 小林純子、岩永敏彦
  • Organizer: 第55回日本解剖学会 東北北海道連合支部学術集会
  • Place of Presentation: 仙台、東北大学 昆稜会館
  • Year and Date: 2009-09-26
• [Presentation] ガラクトサミン誘発性肝炎における抗galectin-3抗体の炎症抑制効果 (2009)
  • Author(s): 小林純子、岩永敏彦
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 高山、飛騨・世界生活文化センター
  • Year and Date: 2009-09-10
• [Presentation] マウスの黄体におけるガレクチン発現細胞の同定と発現パターン (2009)
  • Author(s): 小林純子、岩永敏彦
  • Organizer: 第115回日本解剖学会総会
  • Place of Presentation: 岩手、岩手医科大学
  • Year and Date: 2009-03-29
• [Presentation] 実験的肝炎におけるガレクチンの役割 (2009)
  • Author(s): 小林純子、岩永敏彦
  • Organizer: 第115回日本解剖学会総会
  • Place of Presentation: 岩手、岩手医科大学
  • Year and Date: 2009-03-28
• [Remarks] 研究室ホームページ
  • URL: http://www.med.hokudai.ac.jp/~anat-3w/
• [Remarks] 研究室ホームページ
  • URL: http://www.med.hokudai.ac.jp/~anat-3w/
• [Remarks] 研究室ホームページ
  • URL: http://www.med.hokudai.ac.jp/~anat-3w/