| Project/Area Number |
21790219
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SHINODA Yo The Institute of Physical and Chemical Research, 分子神経形成研究チーム, 研究員 (80403096)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 生理学 / 精神科学 / 脳・神経 / BDNFCA / PS2 / 分泌 / CAPS2 / BDNF / GABA / Interneuron / interneuron / anxiety / secretion |
|---|
| Research Abstract |
Brain derived neurotrophic factor (BDNF) plays critical role in neurogenesis, neuronal survival and development and in synaptic development and plasticity. However, the mechanism of the BDNF secretion is largely unknown. Recently, Ca^<2+> dependent activator protein for secretion 2 (CAPS2) has been discovered as a protein which regulates BDNF secretion. In the present study, we demonstrated that CAPS2 not only accelerates BDNF secretion kinetics but also increases BDNF quantal release by using time-lapse BDNF secretion imaging technique. In addition, CAPS2 regulated BDNF secretion plays a critical role in development of GABAergic interneuron network. The GABAergic interneuron impairments affect synaptic plasticity and anxiety-like behavior.
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