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Generation of conditional knockout of small Maf genes in mice

Research Project

Project/Area Number 21790303
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionTohoku University

Principal Investigator

KATSUOKA Fumiki  Tohoku University, 大学院・医学系研究科, 准教授 (30447255)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords転写因子 / 疾患モデルマウス / 小Maf群因子 / 生体防御
Research Abstract

CNC-small Maf heterodimers are important for the regulation of various cytoprotective genes. This study revealed that small Maf proteins are indispensable for embryogenesis after E9.5, especially for liver development. This study also showed that the neurodegeneration observed in small Maf mutant mice is cell-autonomous effect. Conditional knockout system of small Maf proteins was established and will enable us to examine the function of small Maf proteins in adult tissues.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (24 results)

All 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (16 results)

  • [Journal Article] Central nervous system-specific deletion of transcription factor Nrf1 dcauses progressive motor neuronal dysfunction.2011

    • Author(s)
      kira Kobayashi, Takako Tsukide, Tomohiro Miyasaka, Tomoko Morita, Tatsuya Mizoroki, Yoshiro Saito, Yasuo Ihara, Akihiko Takashima, Noriko Noguchi, Akiyoshi Fukamizu, Yosuke Hirotsu, Makiko Ohtsuji, Fumiki Katsuoka, Masayuki Yamamoto.
    • Journal Title

      Genes Cells 印刷中

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2 degron-fused reporter system ; a new tool for specific evaluation of Nrf2 inducers.2011

    • Author(s)
      Yosuke Hirotsu, Fumiki Katsuoka, Ken Itoh, Masayuki Yamamoto.
    • Journal Title

      Genes Cells 16

      Pages: 406-415

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular determinants for small Maf protein control of platelet production.2011

    • Author(s)
      Hozumi Motohashi, Rie Fujita, Mariko Takayama, Ai Inoue, Fumiki Katsuoka, Emery H.Bresnick, Masayuki Yamamoto.
    • Journal Title

      Mol Cell Biol. 31

      Pages: 151-162

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nrf2 degron-fused reporter system ; a new tool for specific evaluation of Nrf2 inducers.2011

    • Author(s)
      Yosuke Hirotsu, Fumiki Katsuoka, Ken Itoh, Masayuki Yamamoto.
    • Journal Title

      Genes Cells

      Volume: 16 Pages: 406-415

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.2011

    • Author(s)
      Akira Kobayashi, Takako Tsukide, Tomohiro Miyasaka, Tomoko Morita, Tatsuya Mizoroki, Yoshiro Saito, Yasuo Ihara, Akihiko Takashima, Noriko Noguchi, Akiyoshi Fukamizu, Yosuke Hirotsu, Makiko Ohtsuji, Fumiki Katsuoka, Masayuki Yamamoto.
    • Journal Title

      Genes Cells

      Volume: (未定 印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular determinants for small Maf protein control of platelet production.2011

    • Author(s)
      Motohashi H, Fujita R, Takayama M, Inoue A, Katsuoka F, Bresnick EH, Yamamoto M.Molecular determinants for small Maf protein control of platelet production
    • Journal Title

      Mol Cell Biol

      Volume: 31 Pages: 151-162

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation.2010

    • Author(s)
      Hozumi Motohashi, Momoko Kimura, Rie Fujita, Ai Inoue, Xiaoqing Pan, Mariko Takayama, Fumiki Katsuoka, Hiroyuki Aburatani, Emery H.Bresnick, Masayuki Yamamoto.
    • Journal Title

      Blood. 115

      Pages: 677-689

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation2010

    • Author(s)
      Motohashi H, Kimura M, Fujita R, Inoue A, Pan X, Takayama M, Katsuoka F, Aburatani H, Bresnick EH, Yamamoto M.
    • Journal Title

      Blood 115

      Pages: 677-686

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 転写因子Nrf1とNrf2の中枢神経系における機能的差異の検証2010

    • Author(s)
      弘津陽介, 勝岡史城, 小林聡, 山本雅之
    • Organizer
      第83回日本生化学会大会・第33回日本分子生物学会学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 転写因子Nrf1とNrf2の中枢神経系における機能的差異の検証2010

    • Author(s)
      弘津陽介, 勝岡史城, 小林聡, 山本雅之
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Embryonic lethality and fetal liver hypoplasia in mice lacking all three small Maf proteins.2010

    • Author(s)
      Hiromi Yamazaki, Fumiki Katsuoka, Hozumi Motohashi, James Douglas Engel, Masayuki Yamamoto.
    • Organizer
      9th JBS Bio-Frontier Symposium 2010-5th International symposium of GATA factors.
    • Place of Presentation
      仙台
    • Year and Date
      2010-11-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Embryonic lethality and fetal liver hypoplasia in mice lacking all three small Maf proteins.2010

    • Author(s)
      Fumiki Katsuoka, Hiromi Yamazaki, Hozumi Motohashi, James Douglas Engel, Masayuki Yamamoto
    • Organizer
      9th Japanese Biochemical Society (JBS) Bio-Frontier Symposium 2010/5th International Symposium on GATA factors.
    • Place of Presentation
      仙台
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular basis of CNC and small Maf dimer function in neural tissues.2010

    • Author(s)
      Fumiki Katsuoka.
    • Organizer
      Jornada Cien tifica Regulatory mechanisms in inflammatory processes. University of Valencia
    • Place of Presentation
      スペイン、バレンシア
    • Year and Date
      2010-10-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Molecular basis of CNC and small Maf dimer function in neural tissues.2010

    • Author(s)
      Fumiki Katsuoka
    • Organizer
      Jornada Cientifica-Regulatory mechanisms in inflammatory processes
    • Place of Presentation
      スペイン、バレンシア
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Comprehensive analysis of gene expression in central nervous system of small Maf compound mutant mice.2009

    • Author(s)
      弘津陽介、勝岡史城、山本雅之
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Nrf2 is degraded by Keap1-independent proteasome pathway in the absence of small Maf proteins.2009

    • Author(s)
      勝岡史城、中山博未、本橋ほづみ、山本雅之
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-10
    • Related Report
      2010 Final Research Report
  • [Presentation] Nrf2 is degraded by Keap1-independent proteasome pathway in the absence of small Maf proteins2009

    • Author(s)
      勝岡史城, 他
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Comprehensive analysis of gene expression in central nervous system of small Maf compound mutant mice2009

    • Author(s)
      弘津陽介、勝岡史城、山本雅之
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pivotal roles of small Maf proteins in the regulation of stress response genes.2009

    • Author(s)
      Katsuoka F, Motohashi H, Nakayama H, Yamamoto M.
    • Organizer
      The 1st International Symposium "Challenge to Medical Innovation"
    • Place of Presentation
      仙台
    • Year and Date
      2009-12-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Nrf2 is degraded by Keap1-independent degradation pathway in the absence of small Maf proteins.2009

    • Author(s)
      Katsuoka F, Motohashi H, Nakayama H, Yamamoto M.
    • Organizer
      21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス胎生期における小Maf群因子の機能2009

    • Author(s)
      勝岡史城、中山博未、本橋ほづみ、Engel JD, 山本雅之
    • Organizer
      日本生化学会東北支部第75回例会・シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-09
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス胎生期における小Maf群因子の機能2009

    • Author(s)
      勝岡史城, 他
    • Organizer
      日本生化学会東北支部 第75回例会
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス胎生期における小Maf群因子の機能2009

    • Author(s)
      中山博未、勝岡史城、本橋ほづみ、山本雅之
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Nrf2誘導剤スクリーニング系の確立2009

    • Author(s)
      弘津陽介、勝岡史城、山本雅之
    • Organizer
      平成21年度合同班会議「遺伝子情報デコード」
    • Place of Presentation
      富山
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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