Investigation of neuroblastoma tumorigenesis focusing on cell cycle related genes
Project/Area Number |
21790317
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Pathological medical chemistry
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Research Institution | Nagoya University |
Principal Investigator |
MURAKAMI Yuko (TONAMI Yuko) 名古屋大学, 大学院・医学系研究科, COE特任助教 (70405174)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 神経芽腫 / 発がん / 細胞周期 / DNA損傷 / 老化 / 合成致死 / 神経芽種 |
Research Abstract |
We identified Smc2 and Sgo1 as genes which show synthetic lethal or senescence phenotype with MYCN amplification/overexpression. MYCN amplified neuroblastoma cell lines in which these genes are knockdowned showed the accumulation of DNA damage, but MYCN single copy cells did not. Our data indicated that Smc2 regulates various DNA repair genes transcription and Sgo1 is involved in DNA damage repair cooperation with PP2A and cohesin. Additionally, Smc2 works as condensin complex in DNA repair genes transcriptional regulation. Patients bearing neuroblastomas with amplified MYCN would be benefited from decreased Smc2 and Sgo1.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Opposing role of condensing hinge against replication protein A in mitosis and interphase through promoting DNA annealing2011
Author(s)
Akai Y, Kurokawa Y, Nakazawa N, Tonami-Murakami Y, Suzuki Y, Yoshimura SH, Iwasaki H, Shiroiwa Y, Nakamura T, Shibata E, Yanagida M
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Journal Title
Open Biology
Volume: 1
Pages: 110023-110023
Related Report
Peer Reviewed
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