| Project/Area Number |
21790335
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tohoku University |
|---|
Principal Investigator |
KAWANO Mitsuko Tohoku University, 加齢医学研究所, 教育研究支援者 (90422203)
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|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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|---|
| Keywords | 免疫学 / アレルギー |
|---|
| Research Abstract |
Development of newly diagnosis and therapeutics are matter of great urgency, because prevalence of allergic skin disease is increasing explosively. In this research, molecular mechanisms of metal allergy, which is one of delayed-type hypersensitivity, were investigated using mouse model of metal allergy. As a result, specific T cell receptor (TCR) repertoire responsible to metal was identified and up-regulation of co-stimulatory molecule and cytokine was clarified. It is thought that this TCR repertoire and these molecules might be new marker and new therapeutic target of metal allergy, respectively.
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