| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Mutations in the MeCP2 gene are a cause of Rett syndrome. One of feature of Rett syndrome is mental retardation by progressive neurologic developmental disorder. Although it is also known that osteopenia often occurs, the mechanism is unknown. In this study, it was investigated the role of MeCP2 in the bone formation using MeCP2 null femurs. The results of the analysis showed that MeCP2 was not involved in the born formation. The cause of osteopenia in Rett syndrome may be movement problem by neurologic developmental disorder.
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