| Project/Area Number |
21790345
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YAMAMOTO Kouhei Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (50451927)
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| Research Collaborator |
HANAKATA NObutaka 独立行政法人物質材料研究機構, 中核機能部門ナノテクノロジー融合ステーション, ステーション長
HASHIMOTO Jun 東京医科歯科大学, 医学部・医学科
TAKEMURA Taro 独立行政法人物質材料研究機構
ABE Shinya 東京医科歯科大学, 医歯学総合研究科包括病理学分野, 助教
NAGIRI Toshiya 東京医科歯科大学, 医歯学総合研究科包括病理学分野
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 悪性リンパ腫 / 濾胞性リンパ腫 / ショットガンプロテオミクス / レーザーマイクロダイセクション / ファージディスプレイ法 / プロテオミクス / phage display / プロテオーム / LC-MS / MS / 病理 |
|---|
| Research Abstract |
To elucidate mechanism of lymphomagenesis of follicular lymphoma, we examined comprehensive protein detection analysis using laser microdissection and shotgun proteomics. We detected approximately two thousand kinds of proteins, focused on GRHPR and PACAP, which detected frequently in follicular lymphoma, and non-neoplastic follicle respectively. These genes were over-expressed in transcriptional level and each protein expressions are affirmed in human histology sample. This study suggested these genes are the candidate marker in follicular lymphomagenesis, and further molecular biological and functional analyses are desirable.
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