Carcinogenic pathway and prognosis of gastric cancer in young patients : genome instability and DNA methylation

Research Project

Project/Area Number	21790363
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Human pathology
Research Institution	Kitasato University
Principal Investigator	ICHINOE Masaaki Kitasato University, 医学部, 講師 (80365163)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	胃癌 / 若年 / 予後 / 若年胃癌 / MSI / LOH
Research Abstract	Clinicopathological feature of young gastric cancer showed significant preponderance for female occurrence, poorly differentiation and Borrmann 5 type. In background mucosa of young gastric cancer, more neutrophilic infiltration, less atrophy and intestinal metaplasia were observed rather than non-young gastric cancer cases. Further, higher LAT1 expression was observed. The difference was not identified between young gastric cancer cases and non-young gastric cancer cases view point of microsatellite instability and methylation status. However, there was a weak tendency that high prevalence of the loss of hMLH-1 expression in non-young gastric cancer. Therefore, abnormality of DNA repair gene might be correlated with the occurrence of non-young gastric cancer rather than young gastric cancer. Young gastric cancer patients showed better prognosis. However, prognostic factor was not identified in this research.