Role of MAP3Ks in the maintenance of mucosal immune homeostasis
| Project/Area Number |
21790460
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SATO Shintaro The University of Tokyo, 医科学研究所, 助教 (80447333)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 粘膜免疫 / 腸管上皮細胞 / MAP3K / 遺伝子改変マウス / MAP3K3 / MEKK3 / 炎症性腸疾患 / ノックアウトマウス |
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| Research Abstract |
MAP3K family members act at upstream of MAPK such as JNK and p38. Among them, it has been reported that TAK1 and MEKK3 are also involved in the activation of NF-κB in response to several stimuli. We made conditional TAK1-deficient mice including intestinal epithelial cell-specific one (TAK1^<IEC-KO>), and reported the role of TAK1 in vivo. In this study, to elucidate the in vivo role of MEKK3 at IEC, we made and analyzed MEKK3^<IEC-KO> mice, and compared them with TAK1^<IEC-KO> mice. As a result, it was revealed that MEKK3, but not TAK1, was not involved in the activation of NF-κB in IEC. In addition, it was suggested that MEKK3 participated in maintenance of homeostasis of IEC.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Inflammatory Mediator TAK1 Regulates Hair Follicle Morphogenesis and Anagen Induction Shown by Using Keratinocyte-Specific TAK1-Deficient Mice.2010
Author(s)
Sayama K, Kajiya K, Sugawara K, Sato S, Hirakawa S, Shirakata Y, Hanakawa Y, Dai X, Ishimatsu-Tsuji Y, Metzger D, Chambon P, Akira S, Paus R, Kishimoto J, Hashimoto K.
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Journal Title
Related Report
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[Journal Article] Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis.2010
Author(s)
Obata T, Goto Y, Kunisawa J, Sato S, Sakamoto M, Setoyama H, Matsuki T, Nonaka K, Shibata N, Gohda M, Kagiyama Y, Nochi T, Yuki Y, Fukuyama Y, Mukai A, Shinzaki S, Fujihashi K, Sasakawa C, Iijima H, Goto M, Umesaki Y, Benno Y, Kiyono H.
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Journal Title
Proc Natl Acad Sci USA. 107
Pages: 7419-7424
Related Report
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[Journal Article] Intracellular Mycobacterium avium Intersect Transferrin in the Rab11(+) Recycling Endocytic Pathway and Avoid Lipocalin 2 Trafficking to the Lysosomal Pathway.2010
Author(s)
Halaas O, Steigedal M, Haug M, Awuh JA, Ryan L, Brech A, Sato S, Husebye H, Cangelosi GA, Akira S, Strong RK, Espevik T, Flo TH.
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Journal Title
J Infect Dis. 201
Pages: 783-792
Related Report
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[Journal Article] Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity.2009
Author(s)
Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira S, Mimuro H, Sasakawa C, Fukui Y, Fujihashi K, Akiyama T, Inoue J, Penninger JM, Kunisawa J, Kiyono H.
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Journal Title
J Exp Med. 206
Pages: 2351-2364
Related Report
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