| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Type I IFN is important for innate immune response. However, cells producing type I IFN have not been fully identified yet. We generated a knock-in mouse strain where GFP is under control of Ifnb1 gene promoter. Observation of GFP expressing cells on viral or bacterial infection identified IFN-b-producing cells in vivo. IFN-b-producing cells in response to bacterial infection were different from that in viral infection. By crossing with various knock-out mouse strains for signaling molecules, we have identified signaling pathways essential for IFN-b production in response to bacteria in vivo.
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