Protection afforded by a selective thromboxane A2 (TXA2) synthase inhibitor, ozagrel, against drug-induced liver injury.
| Project/Area Number |
21790524
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Kumamoto University |
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Principal Investigator |
ISHITSUKA Yoichi Kumamoto University, 大学院・生命科学研究部, 助教 (70423655)
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| Research Collaborator |
TOMISHIMA Yoshiro 熊本大学, 薬学教育部, 大学院生
MATSUNAGA Naoya 九州大学, 薬学研究科(研究院), 助教
TAKEURA Hiroyuki 熊本赤十字病院, 薬剤部, 薬剤師
OHDO Shigehiro 九州大学, 薬学研究科(研究院), 教授
IRIE Tetsumi 熊本大学, 大学院・+J47生命科学研究部, 教授
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | オザグレル / トロンボキサンA2 / アセトアミノフェン / 肝傷害 / 有害事象 |
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| Research Abstract |
This study was conducted to evaluate the effects of ozagrel, a selective thromboxane A2 synthase inhibitor, against acetaminophen-induced hepatic injury in mouse. Ozagrel effectively attenuated the acetaminophen-induced hepatic damage as indicated by the serum ALT, and oncotic necrosis and nuclear DNA fragmentation in liver in dose- and time-dependent manner. In addition, delayed administration of the ozagrel was more effective than N-acetylcysteine after the acetaminophen liver injury. The results suggest that ozagrel is a promising drug candidate for preventing acetaminophen-induced hepatic injury.
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Report
(3 results)
Research Products
(8 results)
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[Presentation] 非ステロイド性消炎鎮痛薬の使用が困難な成人患者への小児用アセトアミノフェン坐剤の使用およびその有効性と安全性に関する検討2010
Author(s)
竹浦宏幸, 田添光二, 石塚洋一, 入倉充, 上田賢太郎, 岩田一史, 下石和樹, 陣上祥子, 吉田稔, 入江徹美, 福永栄子
Organizer
第20回日本医療薬学会年会
Place of Presentation
千葉市,幕張メッセ
Related Report
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[Presentation] 高用量アセトアミノフェン坐剤の製剤特性及び有効性に関する検討2010
Author(s)
田添光二, 竹浦宏幸, 野田寛子, 石塚洋一, 入倉充, 入江徹美, 吉田稔, 定永明子, 永田浩泰, 陣上祥子, 福永栄子
Organizer
第20回日本医療薬学会年会
Place of Presentation
千葉市,幕張メッセ
Related Report
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