| Project/Area Number |
21790524
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Kumamoto University |
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Principal Investigator |
ISHITSUKA Yoichi Kumamoto University, 大学院・生命科学研究部, 助教 (70423655)
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| Research Collaborator |
TOMISHIMA Yoshiro 熊本大学, 薬学教育部, 大学院生
MATSUNAGA Naoya 九州大学, 薬学研究科(研究院), 助教
TAKEURA Hiroyuki 熊本赤十字病院, 薬剤部, 薬剤師
OHDO Shigehiro 九州大学, 薬学研究科(研究院), 教授
IRIE Tetsumi 熊本大学, 大学院・+J47生命科学研究部, 教授
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | オザグレル / トロンボキサンA2 / アセトアミノフェン / 肝傷害 / 有害事象 |
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| Research Abstract |
This study was conducted to evaluate the effects of ozagrel, a selective thromboxane A2 synthase inhibitor, against acetaminophen-induced hepatic injury in mouse. Ozagrel effectively attenuated the acetaminophen-induced hepatic damage as indicated by the serum ALT, and oncotic necrosis and nuclear DNA fragmentation in liver in dose- and time-dependent manner. In addition, delayed administration of the ozagrel was more effective than N-acetylcysteine after the acetaminophen liver injury. The results suggest that ozagrel is a promising drug candidate for preventing acetaminophen-induced hepatic injury.
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