Study on the molecular basis of the exertion of adverse effects of drugs mediated by regulation of NADPH oxidase activities

• Project/Area Number: 21790525
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied pharmacology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: KATSUYAMA Masato Kyoto Prefectural University of Medicine, 医学研究科, 准教授 (60315934)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: NADPHオキシダーゼ / NOX / 活性酸素 / クリオキノール / Sp3

Research Abstract

NOX is the catalytic subunit of NADPH oxidase, the superoxide-generating enzyme. Among several isoforms of NOX, NOX4 is abundantly expressed in various tissues. The mechanisms of constitutive and ubiquitous expression of NOX4 were clarified using SH-SY5Y and HEK293 cells. Sp3 transcription factor was found to play a key role in the expression of NOX4 in various cell lineages in human.

Research Products

• [Journal Article] Sp3 transcription factor is crucial for transcriptional activation of the human NOX4 gene. (2011)
  • Author(s): Katsuyama M, Hirai H, Iwata K, Ibi M, Matsuno K, Matsumoto M, Yabe-Nishimura C.
  • Journal Title: FEBS J 278 Pages: 964-972
• [Journal Article] Sp3 transcription factor is crucial for transcriptional activation of the human NOX4 gene (2011)
  • Author(s): Katsuyama M, Hirai H, Iwata K, Ibi M, Matsuno K, Matsumoto M, Yabe-Nishimura C.
  • Journal Title: FEBS Journal Volume: 278 Pages: 964-972
  • Peer Reviewed
• [Presentation] クリオキノールの細胞毒性にNOX4/NADPHオキシダーゼが関与する (2010)
  • Author(s): 勝山真人、矢部千尋
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-16