Study on the molecular basis of the exertion of adverse effects of drugs mediated by regulation of NADPH oxidase activities
| Project/Area Number |
21790525
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Applied pharmacology
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
KATSUYAMA Masato Kyoto Prefectural University of Medicine, 医学研究科, 准教授 (60315934)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
|---|
| Keywords | NADPHオキシダーゼ / NOX / 活性酸素 / クリオキノール / Sp3 |
|---|
| Research Abstract |
NOX is the catalytic subunit of NADPH oxidase, the superoxide-generating enzyme. Among several isoforms of NOX, NOX4 is abundantly expressed in various tissues. The mechanisms of constitutive and ubiquitous expression of NOX4 were clarified using SH-SY5Y and HEK293 cells. Sp3 transcription factor was found to play a key role in the expression of NOX4 in various cell lineages in human.
|
Report
(3 results)
Research Products
(3 results)
