Monoclonal antibody against tumour necrosis factor alpha-associated leukoencephalopathy in rheumatoid arthritis
| Project/Area Number |
21790526
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Fukuoka University |
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Principal Investigator |
NISHIOKU Tsuyoshi Fukuoka University, 薬学部, 助教 (90435115)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生物学的製剤 / 白質脳症 / 関節リウマチ / 血液脳関門 / 白質障害 / 免疫抑制 / アデノシン |
|---|
| Research Abstract |
Rheumatoid arthritis (RA) is an autoimmune disease associated with chronic inflammation of the joints. RA has been shown to increase the morbidity of and mortality due to cardiovascular and cerebrovascular diseases. This study was aimed at evaluating a role of S 100A4 in the mediation of blood-brain barrier (BBB) dysfunction in CIA mice. Cerebrovascular permeability and serum levels of S 100A4 were increased in CIA mice. Increased S I00A4 levels in the serum are closely correlated with hyperpermeability of the cerebrovascular endothelium. S 100A4 increased paracellular permeability of the mouse brain capillary endothelial cells (MBECs). S100A4 reduced the expression of occludin, a tight junction protein in MBECs. These findings suggest that S100A4 increases paracellular permeability of MBECs by decreasing expression levels of occludin. The present study highlights a potential role for S 100A4 in BBB dysfunction underlying cerebrovascular diseases in patients with RA.
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Report
(3 results)
Research Products
(26 results)
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[Presentation] 関節炎モデルマウスにおける血液脳関門障害2010
Author(s)
古庄弘宜, 西奥剛, 三浦哲平, 冨田彩乃, 道具伸也, 高田芙友子, 渡辺拓也, 山内淳史, 首藤英樹, 片岡泰文
Organizer
第83回日本薬理学会年会
Place of Presentation
大阪国際会議場(大阪市)
Year and Date
2010-03-17
Related Report
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