A follow up study of fatty liver, lipoprotein particle sizes, and progression of subclinical atherosclerosis in middle aged men.

• Project/Area Number: 21790579
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Public health/Health science
• Research Institution: Shiga University of Medical Science
• Principal Investigator: KADOWAKI Sayaka 滋賀医科大学, 医学部, 客員助教 (60510344)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 社会医学 / 成人保健 / リポ蛋白粒子サイズ / 脂肪肝 / 疫学 / コホート研究 / 潜在性動脈硬化 / LDLコレステロール / 肥満 / メタボリックシンドローム

Research Abstract

This study was attached to a population-based survey of 300 men and its follow up survey after 7 years. We examined the relationship between fat deposition in liver and lipid profile changes by NMR(nuclear magnetic resonance) of both surveys. As a result, progress of the fat deposition in liver of the follow-up survey was related to the smallness of the LDL particle sizes of the baseline/follow up surveys and the greatness of the LDL particle densities at the follow up survey. By this study, the relationships between the progress of the fat deposition in liver and the lipid profile changes over time were clarified.

Research Products

• [Journal Article] Comparability in coronary artery calcium scores on CT scan between two community-based cohort studies (2011)
  • Author(s): Fujiyoshi A, Kadowaki T, Kadowaki S, Sekikawa A, Ohkubo T, Miura K, Edmundowicz D, Budoff MJ, Murata K, Liu K, Ueshima H.
  • Journal Title: Int J Cardiol Volume: 149巻 Pages: 244-5
  • Peer Reviewed
• [Journal Article] Comparability in coronary artery calcium scores on CT scan between two community-based cohort studies (2011)
  • Author(s): Fujiyoshi A, Kadowaki S, et al
  • Journal Title: International journal of cardiology Volume: 149 Pages: 244-245
  • Peer Reviewed
• [Journal Article] Associations of D-dimer and von Willebrand factor with atherosclerosis in Japanese and white men (2010)
  • Author(s): Azuma RW, Kadowaki T, El-Saed A, Ueshima H, Sutton-Tyrrell K, Nakamura Y, Edmundowicz D, Ueno Y, Evans RW, Kadota A, Kuller LH, Murata K, Takamiya T, Kadowaki S, Curb JD, Sekikawa A.
  • Journal Title: Acta Cardiol Volume: 65巻 Pages: 449-56
  • Peer Reviewed
• [Journal Article] Stronger associations of sagittal abdominal diameter with atherogenic lipoprotein subfractions than waist circumference in middle-aged US white and Japanese men (2010)
  • Author(s): Nakata K, Choo J, Hopson MJ, Ueshima H, Curb JD, Shin C, Evans RW, Kadowaki T, Otake T, Kadota A, Kadowaki S, Miura K, El-Saed A, Edmundowicz D, Sutton-Tyrrell K, Kuller LH, Sekikawa A.
  • Journal Title: Metabolism Volume: 59巻 Pages: 1742-51
  • Peer Reviewed
• [Journal Article] Visceral and subcutaneous adiposity and adiponectin in middle-aged Japanese men : the ERA JUMP study (2009)
  • Author(s): Nakamura Y, Sekikawa A, Kadowaki T, Kadota A, Kadowaki S, Maegawa H, Kita Y, Evans RW, Edmundowicz D, Curb JD, Ueshima H.
  • Journal Title: Obesity(Silver Spring) Volume: 17巻 Pages: 1269-73
  • Peer Reviewed
• [Journal Article] Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men (2009)
  • Author(s): Motoyama KR, Curb JD, Kadowaki T, El-Saed A, Abbott RD, Okamura T, Evans RW, Nakamura Y, Sutton-Tyrrell K, Rodriquez BL, Kadota A, Edmundowicz D, Willcox BJ, Choo J, Katsumi N, Otake T, Kadowaki S, Kuller LH, Ueshima H, Sekikawa A.
  • Journal Title: Am J Clin Nutr Volume: 90巻 Pages: 49-55
  • Peer Reviewed
• [Journal Article] Higher liver fat content among Japanese in Japan compared with non-Hispanic whites in the United States (2009)
  • Author(s): Azuma K, Kadowaki T, Cetinel C, Kadota A, El-Saed A, Kadowaki S, Edmundowicz D, Nishio Y, Sutton-Tyrrell K, Okamura T, Evans RW, Takamiya T, Ueshima H, Curb JD, Abbott RD, Kuller LH, Kelley DE, Sekikawa A.
  • Journal Title: Metabolism Volume: 58巻 Pages: 1200-7
  • Peer Reviewed
• [Presentation] Coronary artery calcification is not uncommon among apparently healthy Japanese men and women : results from the Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA) (2012)
  • Author(s): Akira Fujiyoshi, Katsuyuki Miura, Takashi Kadowaki, Sayaka Kadowaki, Hirotsugu Ueshima, et al
  • Organizer: XVI International Symposium on Atherosclerosis
  • Place of Presentation: シドニー/オーストラリア
  • Year and Date: 2012-03-28
• [Presentation] Lipoprotein-associated Phospholipase A2 Related to the Risk of Subclinical Carotid Atherosclerosis in a General Male Japanese population (2012)
  • Author(s): Hirotsugu Ueshima, Takashi Kadowaki, Katsuyuki Miura, Sayaka Kadowaki, et al
  • Organizer: XVI International Symposium on Atherosclerosis
  • Place of Presentation: シドニー/オーストラリア
  • Year and Date: 2012-03-28
• [Presentation] Lipoprotein-associated Phospholipase A2 Related to the Risk of Subclinical Carotid Atherosclerosis in a General Male Japanese Population (2012)
  • Author(s): 上島弘嗣、門脇崇、三浦克之、大久保孝義、藤吉朗、門田文、門脇紗也佳、中村保幸、北徹, 他
  • Organizer: 第76回日本循環器学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-18
• [Presentation] 冠動脈石灰化は日本人一般集団の男女でもまれではない: SESSA研究 (2012)
  • Author(s): 藤吉朗、三浦克之、門脇崇、門脇紗也佳、北徹、上島弘嗣, 他
  • Organizer: 第76回日本循環器学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-17
• [Presentation] 肥満と冠動脈石灰化の関連は日韓米4集団で異なるか:国際横断研究 (2012)
  • Author(s): 藤吉朗、関川暁、大久保孝義、三浦克之、門脇崇、門脇紗也佳、上島弘嗣, 他
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2012-01-27
• [Presentation] 肥満と冠動脈石灰化の関連の強さは日韓米4集団で異なるか:国際横断研究 (2012)
  • Author(s): 藤吉朗、門脇紗也佳, 他
  • Organizer: 日本疫学会
  • Place of Presentation: 東京
• [Presentation] Coronary artery calcification is not uncommon among apparently healthy Japanese men and women (2012)
  • Author(s): 藤吉朗、門脇紗也佳, 他
  • Organizer: 国際動脈硬化学会
  • Place of Presentation: シドニー
• [Presentation] 日米地域住民対象コホートにおけるCTによる冠動脈石灰化スコアの比較可能性検討 (2011)
  • Author(s): 藤吉朗、門脇崇、門脇紗也佳、関川暁、大久保孝義、三浦克之、上島弘嗣, 他
  • Organizer: 第47回日本循環器病予防学会・日本循環器管理研究協議会総会
  • Place of Presentation: 福岡
  • Year and Date: 2011-06-03