The regulation of Paneth cells gene expression by Hath1
Project/Area Number |
21790653
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Gastroenterology
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
TSUCHIYA Kiichirou Tokyo Medical and Dental University, 医学部附属病院, 講師 (40376786)
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Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | Atoh1 / Hath1 / 小腸 / パネート細胞 / 抗菌物質 / FGFシグナル / TCF4 / HD6 / クローン病 / 小腸上皮細胞 / 炎症性腸疾患 |
Research Abstract |
Previous studies have indicated that Hath1 contributes to the differentiation program of Paneth cells, however it remains unknown how Hath1 regulates the Paneth cell gene expression. This study shows the mechanism of phenotypic expression for Paneth cells by Hath1 in human intestine. The present study suggests that Hath1 and beta-catenin are essential for HD6 gene expression by binding to E-box sequence in 5' promoter region of HD6 resulting in the contribution to Paneth cell phenotype.
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] Magnetic resonance enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease.2010
Author(s)
Hyun SB, Kitazume Y, Nagahori M, Toriihara A, Fujii T, Tsuchiya K, Suzuki S, Okada E, Araki A, Naganuma M, Watanabe M.
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Journal Title
Inflamm Bowel Dis. in press
Related Report
Peer Reviewed
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[Journal Article] Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4.2010
Author(s)
Iwasaki M, Tsuchiya K, Okamoto R, Zheng X, Kano Y, Okamoto E, Okada E, Araki A, Suzuki S, Sakamoto N, Kitagaki K, Akashi T, Eishi Y, Nakamura T, Watanabe M
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Journal Title
NAID
Related Report
Peer Reviewed
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