Identification of molecules regulating the development of intestinal pacemaker cells (ICC) and search for ICC stem cell
| Project/Area Number |
21790655
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | University of Fukui |
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Principal Investigator |
HORIGUCHI Kazuhide University of Fukui, 医学部, 講師 (20377451)
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| Co-Investigator(Renkei-kenkyūsha) |
HORIGUCHI Satomi 福井大学, 重点研究高度化推進本部, 特命助教 (00595283)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | カハール介在細胞(ICC) / 消化管 / 発生 / マイクロアレイ / c-KIT / セルソーター / microarray / 小腸 / 骨形成因子 / TGFβ |
|---|
| Research Abstract |
Interstitial cells of Cajal (ICC), which are located in the gastrointestinal musculature, are suggested to be pacemaker cells of the gut motility. In this study we examined the gene expression of ICC precursor cells during the embryonic stage of mice to clarify the genes associated with the development of ICC. By using DNA microarray we found some candidate genes including BMP signaling related genes and TGFβ signaling related genes. In addition we established specific isolation of ICC using a cell sorter.
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Report
(4 results)
Research Products
(14 results)
