Development of immunotherapy using features of innate immunity and liver dendritic cells
| Project/Area Number |
21790669
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Ehime University |
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Principal Investigator |
ABE Masanori Ehime University, 大学院・医学系研究科, 寄附講座准教授 (40432786)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 樹状細胞 / 肝臓 / 自然免疫 |
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| Research Abstract |
In this study, we conducted basic research for the development of immunotherapy using liver dendritic cells (DC) and innate immunity. We found that, due to the hyporesponsiveness to endotxin, liver DC stimulated by innate immune signal had less immunogenicity compared to DC from other organs both in vitro and in vivo. These data indicate that it is necessary to consider the balance between maintenance and break endotoxin tolerance for the development of immunotherapy in liver diseases.
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Report
(3 results)
Research Products
(21 results)
