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Elucidation of mechanisms for hepatic differentiation by HGF

Research Project

Project/Area Number 21790673
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionKumamoto University (2011)
Kagoshima University (2009-2010)

Principal Investigator

TAKAMI Yoichiro  熊本大学, 発生医学研究所, 厚労科研研究員 (10500473)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsHGF / iPS細胞 / 分化誘導 / ミトコンドリア / ips細胞 / 肝細胞増殖因子 / 肝内胚葉 / 脂肪酸代謝 / マイクロアレイ
Research Abstract

The purpose of this study is to elucidate the mechanisms for HGF-promoted hepatic differentiation from iPS cells which are still unknown. In this study, we found that (1) the characters of differentiated cells from iPS cells may change according to the generation procedures of iPS cells, and (2) mitochondrial functions were associated with the feature of differentiated cells and cellular reprogramming

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (38 results)

All 2012 2011 2010 2009

All Journal Article (17 results) (of which Peer Reviewed: 16 results) Presentation (18 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] High serum thioredoxin levels were reduced after tonsillectomy in patients with IgA nephropathy2012

    • Author(s)
      Nosaki T, Uto H, Takami Y, Oku M, Fukumoto M, Mera K, Nishida C, Tokunaga K, Sogabe A, Oketani M, Ido A, Kurono Y, Tsubouchi H
    • Journal Title

      Intern Med

      Volume: 51 Pages: 559-565

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] High Serum Thioredoxin Levels Are Reduced after Tonsillectomy in Patients with IgA Nephropathy2012

    • Author(s)
      Tsuyoshi Nosaki, Hirofumi Uto, Yoichiro Takami, et al
    • Journal Title

      Internal Medicine

      Volume: 51 Issue: 6 Pages: 559-565

    • DOI

      10.2169/internalmedicine.51.6021

    • NAID

      130002061912

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum manganese superoxide dismutase and thioredoxin levels are potential prognostic markers among patients with HCV-related hepatocellular carcinoma2011

    • Author(s)
      Tamai T, Uto H, Takami Y, Oda K, Saishoji A, Hashiguchi M, Kumagai K, Kure T, Mawatari S, Moriuchi A, Oketani M, Ido A, Tsubouchi H
    • Journal Title

      World J Gastroenterol

      Volume: 17 Pages: 4890-4898

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liver regeneration after partial hepatectomy in rat is more impaired in a steatotic liver induced by dietary fructose compaired to dietary fat2011

    • Author(s)
      Tanoue S Uto H, Kumamoto R, Arima S, Hashimoto S, Nasu Y, Takami Y, Moriuchi A, Sakiyama T, Oketani M, Ido A, Tsubouchi H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 407 Pages: 163-168

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical proteomics for liver disease : a promising approach for discovery of novel biomarkers2011

    • Author(s)
      Uto H, Kanmura S, Takami Y, Tsubouchi H
    • Journal Title

      Proteome Sci

      Volume: 8 Pages: 70-70

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liver regeneration after partial hepatectomy in rat is more impaired in a steatotic liver induced by dietary fructose compaired to dietary fat2011

    • Author(s)
      Shirou Tanoue, Hirofumi Uto, Ryo Kumamoto, et al
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 407 Issue: 1 Pages: 163-168

    • DOI

      10.1016/j.bbrc.2011.02.131

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum manganese superoxide dismutase and thioredoxin levels are potential prognostic markers among patients with HCV-related hepatocellular carcinoma2011

    • Author(s)
      Tsutomu Tamai, Hirofumi Uto, Yoichiro Takami, et al
    • Journal Title

      World Journal of Gastroenterology

      Volume: 17 Pages: 4890-4898

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insulin-Like Growth Factor Binding Protein-1 levels are increased in patients with IgA nephropathy2010

    • Author(s)
      Tokunaga K, Uto H, Takami Y, Mera K, Nishida C, Yoshimine Y, Fukumoto M, Oku M, Sogabe A, Nosaki T, Moriuchi A, Oketani M, Ido A, Tsubouchi H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 399 Pages: 144-149

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel biomarker for oxidative stress induced by hydrogen peroxide in primary human hepatocytes using the 2-nitrobenzenesulfenyl chloride isotope labeling method2010

    • Author(s)
      Takami Y, Uto H, Tamai T, Sato Y, Ishida Y, Morinaga H, Sakakibara Y, Moriuchi A, Oketani M, Ido A, Tsubouchi H
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 438-445

    • NAID

      10027291800

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proanthocyanidin derived from the leaves of Vaccinium virgatum suppresses platelet-derived growth factor. induced proliferation of the human hepatic stellate cell line LI902010

    • Author(s)
      Takami Y, Uto H, Takeshita M, Kai H, Akamatsu E, Moriuchi A, Hasegawa S, Oketani M, Ido A, Kataoka H, Tsubouchi H
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 337-345

    • NAID

      10027407999

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proanthocyanidin derived from the leaves of Vaccinium virgatum suppresses platelet-derived growth factor-induced proliferation of the human hepatic stellate cell line LI90.2010

    • Author(s)
      Takami Y, Uto H, et al
    • Journal Title

      Hepatology Research

      Volume: 40 Pages: 337-345

    • NAID

      10027407999

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel biomarker for oxidative stress induced by hydrogen peroxide in primary human hepatocytes using the 2-nitrobenzenesulfenyl chloride isotope labeling method.2010

    • Author(s)
      Takami Y, Uto H, et al
    • Journal Title

      Hepatology Research

      Volume: 40 Pages: 438-445

    • NAID

      10027291800

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insulin-like growth factor binding protein-1 levels are increased in patients with IgA nephropathy.2010

    • Author(s)
      Tokunaga K, Uto H, et al
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 399 Pages: 144-149

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical proteomics for liver disease : a promising approach for discovery of novel biomarkers.2010

    • Author(s)
      Uto H, Kanmura S, et al
    • Journal Title

      Proteome Science

      Volume: 8 Pages: 70-79

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proanthocyanidin derived from the leaver of Vaccinium virgatum suppresses platelet-derived growth factro-induced proliferation of the human hepatic stellate cell line LI902010

    • Author(s)
      Yoichiro Takami
    • Journal Title

      Hepatology Research 40

      Pages: 337-345

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel biomarker for oxidative stress induced by hydrogen peroxide in primary human hepatocytes using the 2-nitrobenzenesulfenyl chloride isotope labeling method2010

    • Author(s)
      Yoichiro Takami
    • Journal Title

      Hepatology Research 40

      Pages: 338-345

    • NAID

      10027291800

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肝発癌予防につながる高機能性食品の探索2009

    • Author(s)
      宇都浩文、高見陽一郎、坪内博仁
    • Journal Title

      Functional Food

      Volume: Vol.3 Pages: 150-154

    • Related Report
      2011 Final Research Report
  • [Presentation] 難治性疾患由来外来因子フリーiPS細胞の樹立2012

    • Author(s)
      高見陽一郎、山田祥慎、片山朋彦、濱崎誠、房木ノエミ、江良択実
    • Organizer
      第8回宮崎サイエンスキャンプ
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎)
    • Year and Date
      2012-02-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Serum manganese superoxide dismutase and thioredoxin levels may predict mortality in patients with hepatitis C virus-related hepatocellular carcinoma2011

    • Author(s)
      Tamai T, Uto H, Takami Y, Oda K, Saishoji A, Hashiguchi M, Kure T, Kumagai K, Mawatari S, Moriuchi A, Oketani M, Ido A, Tsubouchi H
    • Organizer
      The International Liver Cancer Association 2011 Fifth Annual Conference
    • Place of Presentation
      Hong Kong Convention and Exhibition Centre(Hong Kong, China)
    • Year and Date
      2011-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Serum manganese superoxide dismutase and thioredoxin levels may predict mortality in patients with hepatitis C virus-related hepatocellular carcinoma2011

    • Author(s)
      Tsutomu Tamai, Hirofumi Uto, Yoichiro Takami, et al
    • Organizer
      The International Liver Cancer Association 2011 Fifth Annual Conference
    • Place of Presentation
      Hong Kong Convention and Exhibition Centre (Hong Kong)
    • Year and Date
      2011-09-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Clinical significance of serum MnSOD levels in patients with hepatitis C virus(HCV)-related chronic liver disease2010

    • Author(s)
      Tamai T, Uto H, Takami Y, Saishoji A, Hashiguchi M, Kumagai K, Kure T, Mawatari S, Moriuchi A, Oketani M, Ido A, Tsubouchi H
    • Organizer
      The 7th APASL Single Topic Conference "Hepatitis C Virus"
    • Place of Presentation
      Makuhari Messe(Chiba, Japan)
    • Year and Date
      2010-12-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 誘導型多能性幹細胞(iPS細胞)は肝細胞への分化過程で脂肪化した肝細胞様細胞を生じる2010

    • Author(s)
      高見陽一郎、宇都浩文、佐藤悠子、熊谷公太郎、呉建、玉井努、森内昭博、嵜山敏男、桶谷真、井戸章雄、坪内博仁
    • Organizer
      第42回日本臨床分子形態学会・学術集会
    • Place of Presentation
      東レ総合研修センター(静岡)
    • Year and Date
      2010-09-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 誘導型多能性幹細胞(ips細胞)は肝細胞への分化過程で脂肪化した肝細胞様細胞を生じる2010

    • Author(s)
      高見陽一郎、宇都浩文, 他
    • Organizer
      第42回日本臨床分子形態学会・学術集会
    • Place of Presentation
      三島市
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] ALTが正常を持続するC型肝炎ウイルス持続感染者の血清プロテオミクス2010

    • Author(s)
      佐藤悠子、宇都浩文、高見陽一郎、佐々木文郷、熊谷公太郎、最勝寺晶子、小田耕平、呉建、馬渡誠一、玉井努、森内昭博、桶谷真、井戸章雄、中島知明、岡上武、坪内博仁
    • Organizer
      日本プロテオーム学会2010年会
    • Place of Presentation
      東京ベイホテル東急(東京)
    • Year and Date
      2010-07-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 腸管マクロファージに発現するオステオアクチビンは腸炎を軽減する2010

    • Author(s)
      佐々木文郷、井戸章雄、高見陽一郎、熊谷公太郎、岩下祐司、指宿和成、隈元亮、上村修司、嵜山敏男、宇都浩文、桶谷真、坪内博仁
    • Organizer
      第47回日本消化器免疫学会総会
    • Place of Presentation
      大津プリンスホテル(滋賀)
    • Year and Date
      2010-07-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 血清MnSODは非アルコール性脂肪肝炎とHCV関連慢性肝疾患のバイオマーカーである2010

    • Author(s)
      高見陽一郎、宇都浩文, 他
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形市
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血清MnSODは非アルコール性脂肪肝炎とHCV関連慢性肝疾患のバイオマーカーである2010

    • Author(s)
      高見陽一郎、宇都浩文、玉井努、最勝寺晶子、橋口正史、熊谷公太郎、呉建、馬渡誠一、森内昭博、桶谷真、井戸章雄、佐藤悠子、中島知明、岡上武、坪内博仁
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      ホテルメトロポリタン山形(山形)
    • Year and Date
      2010-05-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Hepatocyte growth factor stimulates the migration of gastric epithelial cells by altering the intracellular localization of the tight junction protein ZO-1 Digestive Disease Week(DDW) 20102010

    • Author(s)
      Nasu Y, Ido A, Tanoue S, Hashimoto S, Sasaki F, Takami Y, Kanmura S, Setoyama H, Funakawa K, Moriuchi A, Sakiyama T, Uto H, Oketani M, Tsubouchi H
    • Organizer
      New Orleans Ernest N. Morial Convention Center
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2010-05-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 炎症性腸疾患における炎症のフィードバック調節因子osteoactivinの役割の解明2010

    • Author(s)
      佐々木文郷、井戸章雄、高見陽一郎、熊谷公太郎、上村修司、森内昭博、嵜山敏男、宇都浩文、桶谷真、坪内博仁
    • Organizer
      第96回日本消化器病学会総会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2010-04-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 血清MnSOD濃度の非アルコール性脂肪性肝疾患における臨床的有用性の検討2009

    • Author(s)
      高見陽一郎
    • Organizer
      第17回日本消化器関連学会週間
    • Place of Presentation
      京都
    • Year and Date
      2009-11-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] The serum levels of manganese superoxide dismutase(MnSOD) are elevated in patients with non-alcoholic steatohepatitis(NASH) American Association for the Study of Liver Diseases(AASLD) 60th The Liver Meeting 20092009

    • Author(s)
      Takami Y, Uto H, Tamai T, Satoh Y, Moriuchi A, Funakawa K, Sakiyama T, Oketani M, Ido A, Nakajima T, Okanoue T, Tsubouchi H
    • Organizer
      Hynes Convention Center
    • Place of Presentation
      Boston, USA
    • Year and Date
      2009-11-02
    • Related Report
      2011 Final Research Report
  • [Presentation] The serum levels of manganese superoxide dismutase (MnSOD) are elevated in patients with non-alcoholic steatohepatitis (NASH)2009

    • Author(s)
      Yoichiro Takami
    • Organizer
      American Association for the Study of Liver Diseases (AASLD) 60th The Liver Meeting 2009
    • Place of Presentation
      Boston, USA
    • Year and Date
      2009-11-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血清MnSOD濃度の非アルコール性脂肪性肝疾患における臨床的有用性の検討2009

    • Author(s)
      高見陽一郎、宇都浩文、玉井努、佐藤悠子、熊谷公太郎、呉建、馬渡誠一、森内昭博、長谷川将、桶谷真、井戸章雄、中島知明、岡上武、坪内博仁
    • Organizer
      第17回日本消化器関連学会週間
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2009-10-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Proanthocyanidinはplatelet-derived growth factorによる肝星細胞の活性化を抑制する2009

    • Author(s)
      高見陽一郎、宇都浩文、竹下正彦、甲斐久博、赤松絵奈、森内昭博、長谷川将、桶谷真、井戸章雄、片岡寛章、坪内博仁
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Year and Date
      2009-06-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Proanthocyanidinはplatelet-derived growth factorによる肝星細胞の活性化を抑制する2009

    • Author(s)
      高見陽一郎
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 肝線維化抑制剤2011

    • Inventor(s)
      高見陽一郎、坪内博仁、宇都浩文、片岡寛章、竹下正彦
    • Industrial Property Rights Holder
      財団法人宮崎県産業支援財団、国立大学法人鹿児島大学、国立大学法人宮崎大学、南日本酪農協同株式会社
    • Acquisition Date
      2011-09-16
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 非アルコール性脂肪性肝炎を推定するための検出方法2009

    • Inventor(s)
      坪内博仁、宇都浩文、岡上武、高見陽一郎
    • Industrial Property Rights Holder
      財団法人宮崎県産業支援財団、国立大学法人鹿児島大学
    • Industrial Property Number
      2009-131853
    • Filing Date
      2009-06-01
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 非アルコール性脂肪性肝炎を推定するための検出方法2009

    • Inventor(s)
      高見陽一郎
    • Industrial Property Rights Holder
      財団法人宮崎県産業支援財団
    • Industrial Property Number
      2009-131853
    • Filing Date
      2009-06-01
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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