Revascularization of renal artery and regulation of systemic atherosclerosis.
Project/Area Number |
21790731
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Kyushu University |
Principal Investigator |
MUKAI Yasushi Kyushu University, 大学病院, 助教 (40444856)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 心腎連関 / 動脈硬化症 / 腎血行再建術 / 画像診断 |
Research Abstract |
Patients with renal artery stenosis had significantly greater region of atherosclerotic change in the Aorta than did patients with no renal artery stenosis, evaluated by MRI and FDG-PET. The expression of chemokines and cytokines such as MCP-1 or IL-1β was significantly enhanced in patients with renal artery stenosis, suggesting their roles for the development of more advanced atherosclerosis. Revascularization with angioplasty for renal artery stenosis significantly decreasd the expression of the chemokine, which may have significant anti-atherosclerotic effect.
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Report
(3 results)
Research Products
(3 results)