A novel function of Toll-like receptors on the water-electrolytes secretions from airway submucosal glands

• Project/Area Number: 21790761
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: TAMADA Tsutomu 東北大学, 病院, 助教 (80396473)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 気道粘膜下腺 / パッチクランプ / Toll様受容体 / 粘膜免疫 / LPS / Nitric oxide / アセチルコリン / 電解質分泌 / cGK

Research Abstract

Airway secretions are well controlled in both physiologic and pathologic conditions. Toll-like receptors (TLRs)recognize distinct pathogen associated molecular patterns and activate innate immune responses. In the present study, we showed that the TLR4 ligand could potentiate the secretion of electrolytes from swine tracheal gland acinar cells. This may offer a new therapeutic candidate for controlling airway secretions in the future.

Research Products

• [Journal Article] Toll like receptor 4 potentiates Ca2+ dependent electrolyte secretion from swine tracheal glands Am J Respir (2011)
  • Author(s): Murakami K., T. Tamada, M. Nara, S. Muramatsu, T. Kikuchi, M. Kanehira, Y. Maruyama, M. Ebina and T. Nukiwa.
  • Journal Title: Cell Mol Biol Volume: 45 Pages: 1101-1110
  • Peer Reviewed
• [Journal Article] Toll-like receptor 4 potentiates Ca2+-dependent secretion of electrolytes from swine tracheal glands (2011)
  • Author(s): Murakami K, Tamada T, Nara M, Muramatsu S, Kikuchi T, Kanehira M, Maruyama Y, Ebina M, Nukiwa T
  • Journal Title: Am J Respir Cell Mol Biol Volume: 45 Issue: 5 Pages: 1101-1110
  • DOI: 10.1165/rcmb.2011-0020oc
  • Peer Reviewed
• [Presentation] The effects of clinically-used phosphodiesterase inhibitors on Ca2+-dependent electrolytes secretion from airway submucosal gland. (2011)
  • Author(s): Muramatsu, S., T. Tamada, M. Nara, K. Murakami, M. Ebina and T. Nukiwa.
  • Organizer: ATS 2011 International Conference
  • Place of Presentation: Denver, CO USA
  • Year and Date: 2011-05-15
• [Presentation] Toll-like receptor 4 signaling as a potentiator in the airway submucosal gland secretion (2011)
  • Author(s): Murakami, K., T.Tamada, M.Nara, S.Muramatsu, T.Kikuchi, M.Kanehira, M.Ebina, T.Nukiwa
  • Organizer: ATS 2011 International Conference
  • Place of Presentation: Denver, CO, U.S.A
  • Year and Date: 2011-05-15
• [Presentation] The effects of clinically-used phosphodiesterase inhibitors on Ca^<2+>-dependent electrolytes secretion from airway submucosal gland (2011)
  • Author(s): Muramatsu, S., T.Tamada, M.Nara, K.Murakami, M.Ebina, T.Nukiwa
  • Organizer: ATS 2011 International Conference
  • Place of Presentation: Denver, CO, U.S.A
  • Year and Date: 2011-05-15
• [Presentation] Toll-like receptor 4 signaling as a potentiator in the airway submucosal gland secretion. (2011)
  • Author(s): Murakami, K., T. Tamada, M. Nara, S. Muramatsu, T. Kikuchi, M. Kanehira, M. Ebina and T. Nukiwa.
  • Organizer: ATS 2011 International Conference
  • Place of Presentation: Denver, CO USA
  • Year and Date: 2011-05-05
• [Presentation] 気道粘膜下腺細胞におけるToll様受容体4シグナリングによる分泌調節機序の検討 (2011)
  • Author(s): 村上康司, 玉田勉, 奈良正之, 村松聡士, 菊地利明, 兼平雅彦, 海老名雅仁, 貫和敏博
  • Organizer: 第51回日本呼吸器学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-24
• [Presentation] 気道粘膜下腺細胞からの電解質分泌に対するPDE阻害効果の影響 (2011)
  • Author(s): 村松聡士, 玉田勉, 奈良正之, 村上康司, 海老名雅仁, 貫和敏博
  • Organizer: 第51回日本呼吸器学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-24
• [Presentation] TLR4 signaling as a potentiator in the airway submucosal gland secretion. (2010)
  • Author(s): Murakami, K., T. Tamada, M. Nara, S. Muramatsu, T. Kikuchi, M. Kanehira, M. Ebina and T. Nukiwa.
  • Organizer: European Respiratory Society Annual Congress
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-09-20
• [Presentation] TLR4 signaling as a potentiator in the airway submucosal gland secretion. (2010)
  • Author(s): Murakami, K., T.Tamada, 他
  • Organizer: European Respiratory Society Annual Congress, September 18-22, 2010
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-09-20
• [Presentation] Adenosine 5'-triphosphate (ATP)によるブタ気道平滑筋の収縮機構 (2010)
  • Author(s): 奈良正之、長岡深雪、玉田勉、田村弦、本郷道夫
  • Organizer: 第52回日本平滑筋学会総会(シンポジウム:炎症と平滑筋)
  • Place of Presentation: 仙台
  • Year and Date: 2010-06-30
• [Presentation] Toll-like receptor signaling as a potentiator in the airway submucosal gland secretion. (2010)
  • Author(s): Murakami, K., T.Tamada, 他
  • Organizer: ATS 2010 International Conference, May 14-19, 2010
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 2010-05-19
• [Presentation] Toll-like receptor signaling as a potentiator in the airway submucosal gland secretion. (2010)
  • Author(s): Murakami, K., T. Tamada, M. Nara, T. Kikuchi, M. Ebina and T. Nukiwa.
  • Organizer: ATS 2010 International Conference
  • Place of Presentation: New Orleans, LA USA
  • Year and Date: 2010-05-15
• [Presentation] 気道粘膜下腺細胞におけるToll様受容体シグナリングによる分泌調節機序の検討 (2010)
  • Author(s): 村上康司、玉田勉、奈良正之、菊地利明、海老名雅仁、貫和敏博
  • Organizer: 第50回日本呼吸器学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-04-23