Control of bronchial asthma via Fc receptors on basophils

• Project/Area Number: 21790770
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Kobe University
• Principal Investigator: FUNADA Yasuhiro 神戸大学, 医学部附属病院, 助教 (60437465)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 気管支喘息 / 好塩基球 / Fcレセプター / 抗原特異的IgG

Research Abstract

In wild type mice, total cells and eosinophils in BAL fluid reduced after instillation with anti-OVA IgG1. Anti-OVA IgG1 suppressed airway inflammation in hyperresponsiveness and histology. These effects were lacking in Fc_YRIIB knockout mice. The deficit mice of basophils could not be sensitized allergic antigen and be taken a bronchial asthma. There were no significant difference in basophils activity derived from bone marrows of wild type mice and from that of Fc_YRIIB knockout mice.

Research Products

• [Journal Article] Antigen-Specific IgG ameliorates allergic airway inflammation via Fcγreceptor IIB on dendritic cells (2011)
  • Author(s): Ishikawa Y, Kobayashi K, Yamamoto M, Nakata K, Takagawa T, Funada Y, Kotani Y, Karasuyama H, Yoshida M, Nishimura Y.
  • Journal Title: Respir Res. Volume: 12 Pages: 42-42
• [Journal Article] Antigen-Specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells (2011)
  • Author(s): Ishikawa Y., et al
  • Journal Title: Respir Res Volume: 12(1) Pages: 42-51
  • Peer Reviewed
• [Journal Article] The inhibitory effects of intravenous administration of rabbit immunoglobulin G on airway inflammation are dependent upon Fcγreceptor IIb on CD11c(+) dendritic cells in a murine model (2010)
  • Author(s): Yamamoto M, Kobayashi K, Ishikawa Y, Nakata K, Funada Y, Kotani Y, Masuda A, Takai T, Azuma T, Yoshida M, Nishimura Y.
  • Journal Title: Clin Exp Immunol Volume: 162(2) Pages: 315-24
• [Journal Article] The inhibitory effects of intravenous administration of rabbit immunoglo bulin G on airway inflammation are dependent upon Fcγ receptor IIb on CD11c(+) dendritic cells in a murine model. (2010)
  • Author(s): Yamamoto M, Kobayashi K, Ishikawa Y, et al.
  • Journal Title: Clin Exp Immunol. Volume: 162(2) Pages: 315-324
  • Peer Reviewed
• [Presentation] Antigen Specific IgG suppresses the Dendritic Cells activation via FcγReceptor IIB in asthma (2010)
  • Author(s): Y. Ishikawa, Y Funada, et. al.
  • Organizer: APSR 2010
  • Place of Presentation: マニラ
  • Year and Date: 2010-11-24
• [Presentation] Antigen Specific IgG suppresses the Dendritic Cells activation via FcγReceptor IIB in asthma (2010)
  • Author(s): Y Ishikawa, et al.
  • Organizer: APSR 2010
  • Place of Presentation: マニラ、(フィリピン)
  • Year and Date: 2010-11-24
• [Presentation] Intratrachial instillation of antigen specific IgG inhibits an allergic airway inflammation via FcγreceptorIIB on dendritic cells (2009)
  • Author(s): Y. Ishikawa, Y Funada, et. al.
  • Organizer: World Allergy congress 2009
  • Place of Presentation: ブエノスアイレス
• [Presentation] Intratrachial instillation of antigen specific IgG inhibits an allergic airway inflammation via Fcγreceptor II B on dendritic cells (2009)
  • Author(s): Y.Ishikawa, Y.Funada, et al.
  • Organizer: World Allergy congress 2009
  • Place of Presentation: ブエノスアイレス(アルゼンチン)