Functional analysis of the ER stress response in the development of lung cancer metastasis
Project/Area Number |
21790775
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Respiratory organ internal medicine
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Research Institution | Kumamoto University |
Principal Investigator |
ENDO Motoyoshi Kumamoto University, 大学院・生命科学研究部, 助教 (40398243)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 肺癌 / 転移 / 血管新生 / 小胞体ストレス / 血管新生因子 / 浸潤・転移 / アンジオポエチン様因子 / 低酸素・低栄養 / Angpt12 / サイトカイン / アポトーシス |
Research Abstract |
We examined the involvement of ER stress response in the development of lung metastases by using human lung cancer cell lines. High metastatic strain had high susceptibility to ER stress compared to low metastatic strain. From these results, high metastatic starin might take advantage of ER stress pathway for development of metastasis. In addition, we found that Angptl, which was an angiogenic and lymphangiogenic factor, was induced by ER stress stimuli. From these results, we supposed Angptl induced by ER stress response developed favorable environments for tumor invasion and metastasis.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] C/EBP Homologous Protein Deficiency Attenuates Myocardial Reperfusion Injury by Inhibiting Myocardial Apoptosis and Inflammation.2010
Author(s)
Miyazaki Y, Kaikita K, Endo M, Horio E, Miura M, Tsujita K, Hokimoto S, Yamamuro M, Iwawaki T, Gotoh T, Ogawa H, Oike Y.
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Journal Title
Arterioscler Thromb.Vasc.Biol. 31
Pages: 1124-1132
Related Report
Peer Reviewed
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[Journal Article] The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques.2010
Author(s)
Tsukano H, Gotoh T, Endo M, Miyata K, Tazume H, Kadomatsu T, Yano M, Iwawaki T, Kohno K, Araki K, Mizuta H, Oike Y.
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Journal Title
Arterioscler Thromb.Vasc.Biol. 30
Pages: 1925-1932
Related Report
Peer Reviewed
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[Journal Article] Synoviocyte-derived angiopoietin-like protein 2 contributes to synovial chronic inflammation in rheumatoid arthritis.2010
Author(s)
Okada T, Tsukano H, Endo M, Tabata M, Miyata K, Kadomatsu T, Miyashita K, Semba K, Nakamura E, Tsukano M, Mizuta H, Oike Y.
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Journal Title
Am.J.Pathol. 176
Pages: 2309-2319
Related Report
Peer Reviewed
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[Journal Article] Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance.2009
Author(s)
Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, Kaikita K, Miyashita K, Iwawaki T, Shimabukuro M, Sakaguchi K, Ito T, Nakagata N, Yamada T, Katagiri H, Kasuga M, Ando Y, Ogawa H, Mochizuki N, Itoh H, Suda T, Oike Y.
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Journal Title
Cell Metab. 10
Pages: 178-188
Related Report
Peer Reviewed
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[Journal Article] Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma.2009
Author(s)
Shinriki S, Jono H, Ota K, Ueda M, Kudo M, Ota T, Oike Y, Endo M, Ibusuki M, Hiraki A, Nakayama H, Yoshitake Y, Shinohara M, Ando Y.
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Journal Title
Clin.Cancer Res. 15
Pages: 5426-5434
Related Report
Peer Reviewed
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[Journal Article] Angiopoietins contribute to lung development by regulating pulmonary vascular network formation.2009
Author(s)
Hato T, Kimura Y, Morisada T, Koh GY, Miyata K, Tabata M, Kadomatsu T, Endo M, Urano T, Arai F, Araki K, Suda T, Kobayashi K, Oike Y.
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Journal Title
Biochem.Biophys.Res.Commun. 381
Pages: 218-223
Related Report
Peer Reviewed
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