Skin barrier dysfunction and asthma

• Project/Area Number: 21790786
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Keio University
• Principal Investigator: WAKAKI Misa 慶應義塾大学, 医学部, 共同研究員 (30338032)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 気管支喘息 / 皮膚バリア / 抗原感作 / 気道過敏性 / 経皮感作 / バリア機能障害 / 喘息モデル / インターロイキン17 / インターロイキン23

Research Abstract

Allergen sensitization through a disrupted skin barrier plays a prominent role in the development of atopic diseases, including allergic asthma. The present study has clarified that skin-mediated allergen sensitization results in the prolonged airway inflammation and bronchial hyper-responsiveness in IL-23/IL-17-dependent manner.

Research Products

• [Journal Article] Strain-specific phenotypes of airway inflammation and bronchial hyperresponsiveness induced by epicutaneous allergen sensitisation in BALB/c and C57BL/6 mice (2010)
  • Author(s): M. Kodama, K. Asano, T. Oguma, S. Kagawa, K. Tomomatsu, M. Wakaki, T. Takihara, S. Ueda, N. Ohmori, H. Ogura, J. Miyata, K. Tanaka, N. Kamiishi, K. Fukunaga, K. Sayama, E. Ikeda, T. Miyasho, A. Ishizaka
  • Journal Title: Int Arch Allergy Immunol Volume: 152 Pages: 67-74
  • Peer Reviewed
• [Journal Article] Strain-specific phenotypes of airway inflammation and bronchial responsiveness in duced by epicutaneous allergen sensitization in Balb/c and C57BL/6 mice (2010)
  • Author(s): Motohiro Kodama, Misa Wakaki, et.al.
  • Journal Title: Int Arch Allergy Immunol Volume: 152 Pages: 67-74
  • Peer Reviewed
• [Journal Article] Strain-specific phenotypes of airway inflammation and bronchial responsiveness in duced bv epicutaneous allergen sensitization in Balb/c and C57BL/6 mice (2010)
  • Author(s): Motohiro Kodama, Misa Wakaki, et. al.
  • Journal Title: Int Arch Allergy Immunol 152(in press)
  • Peer Reviewed
• [Presentation] Prolonged airway inflammation and responsiveness in mice sensitized via the skin is IL-23-dependent (2011)
  • Author(s): K Asano, M Kodama, M Wakaki, S Kagawa, T Oguma, K Fukunaga, Y Suzuki, K Sayama, D Cua
  • Organizer: ATS 2011 International Conference
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-16
• [Presentation] 経皮抗原感作による遷延性気道炎症・過敏性亢進とIL-17/IL-23 (2011)
  • Author(s): 樹神元博、鈴木雄介、小熊剛、若木美佐、加川志津子、加畑宏樹、上石修史、田中希宇人、宮田純、小倉裕美、友松克允、福永興壱、佐山宏一、浅野浩一郎
  • Organizer: 第51回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-22
• [Presentation] 経皮抗原感作マウスにおける気道炎症と気道過敏性亢進の遷延 (2010)
  • Author(s): 樹神元博、若木美佐, 他
  • Organizer: 第60回日本アレルギー学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-11-26
• [Presentation] 経皮抗原感作マウスにおける気道炎症と気道過敏性亢進の遷延 (2010)
  • Author(s): 樹神元博、小熊剛、加川志津子、加畑宏樹、上石修史、田中希宇人、宮田純、小倉裕美、友松克允、若木美佐、塩見哲也、福永興壱、佐山宏一、浅野浩一郎
  • Organizer: 第60回日本アレルギー学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-25
• [Presentation] 経皮抗原感作喘息モデルマウスの検討 (2009)
  • Author(s): 樹神元博、浅野浩一郎、小熊剛、加川志津子、若木美佐、友松克充, 小倉裕美, 宮田純, 堀内奈緒, 上田壮一郎、佐山宏一、石坂彰敏
  • Organizer: アレルギー好酸球研究会2009
  • Place of Presentation: 東京
  • Year and Date: 2009-06-19
• [Presentation] 経皮抗原感作喘息モデルマウスの作成 (2009)
  • Author(s): 樹神元博、浅野浩一郎、小熊剛、加川志津子、宮田純、小倉裕美、友松克允、堀内奈緒、上田壮一郎、滝原崇久、加行淳子、新美京子、若木美佐、福永興壱、佐山宏一、石坂彰敏
  • Organizer: 第49回日本呼吸器学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-12
• [Presentation] 経皮抗原感作喘息モデルマウスの作成 (2009)
  • Author(s): 樹神元博、若木美佐, 他
  • Organizer: 日本呼吸器学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2009-06-12