A pathological study of the Aquaporin 4 associated disease Neuromyelitis Optica

• Project/Area Number: 21790829
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: Tohoku University
• Principal Investigator: MISU Tatsuro Tohoku University, 大学院・医学系研究科, 助教 (00396491)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 視神経脊髄炎 / 多発性硬化症 / アクアポリン4抗体 / アストロサイト / GFAP / アクアポリン4 / オリゴデンドロサイト / 脱髄 / 神経病理 / 神経免疫

Research Abstract

We revealed that anti-AQP4 antibody was pathogenic in vitro and in vivo, and we reported several papers to suggest the clinical features, clinical biomarkers, or therapeutic strategy related to aquaporin 4 autoimmunity of neuromyelitis optica.

Research Products

• [Journal Article] Characteristic brain magnetic resonance imaging abnormalities in central nervous system aquaporin-4 autoimmunity. (2010)
  • Author(s): Kim W, Park MS, Lee SH, Kim SH, Jung IJ, Takahashi T, Misu T, et al.
  • Journal Title: Mult Scler 16 Pages: 1229-1236
  • Peer Reviewed
• [Journal Article] Astrocytic damage is far more severe than demyelination in NMO : a clinical CSF biomarker study. (2010)
  • Author(s): Takano R, Misu T, Takahashi T, et al.
  • Journal Title: Neurology 75 Pages: 208-216
  • Peer Reviewed
• [Journal Article] Inflammation induced by innate immunity in the central nervoius system leads to primary astrocyte dysfunction followed by demyelination. (2010)
  • Author(s): Sharma R, Fischer MT, Bauer J, Felts PA, Smigh KJ, Misu T, et al.
  • Journal Title: Acta Neuropathol 120 Pages: 223-236
  • Peer Reviewed
• [Journal Article] Neuromyelitis optica preceded by hyoerCKemia episode. (2010)
  • Author(s): Suzuki N, Takahashi T, Aoki M, Misu T, et al.
  • Journal Title: Neurology 74 Pages: 1543-1545
  • Peer Reviewed
• [Journal Article] Neuromyelitis optica preceded by hyperCKemia (2010)
  • Author(s): Suzuki N, et al
  • Journal Title: Neurology Volume: 74 Pages: 1543-1545
  • Peer Reviewed
• [Journal Article] Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination (2010)
  • Author(s): Sharma R, et al
  • Journal Title: Acta Neuropathol Volume: 120 Pages: 223-236
  • Peer Reviewed
• [Journal Article] Astrocytic damage is far more severe than demyehnation in NMO : a clinical CSF biomarker study (2010)
  • Author(s): Takano R, et al
  • Journal Title: Neurology Volume: 75 Pages: 208-216
  • Peer Reviewed
• [Journal Article] Neuromyelitis optica : pathogenicity of patient immunoglobulin in vivo. (2009)
  • Author(s): Bradl M, Misu T, Takahashi T, et al.
  • Journal Title: Ann Neurol 66 Pages: 630-643
  • Peer Reviewed
• [Journal Article] A case of NMO seropositive for aquaporin-4 antibody more than 10 years before onset. (2009)
  • Author(s): Nishiyama S, Ito T, Misu T, et al.
  • Journal Title: Neurology 72 Pages: 1960-1961
  • Peer Reviewed
• [Journal Article] Occurrence of acute large and edematous callosal lesions in neuromyelitis optica. (2009)
  • Author(s): Nakamura M, Misu T, Fujihara K, et al.
  • Journal Title: Mult Scler 15 Pages: 695-700
  • Peer Reviewed
• [Journal Article] Marked increase in cerebrospinal fluid glial fibrillary acidic protein in neuromyelitis optica : an astrocytic damage marker. (2009)
  • Author(s): Misu T, Takano R, Fujihara K, et al.
  • Journal Title: J Neurol Neurosurg Psychiatry 80 Pages: 575-577
  • Peer Reviewed
• [Journal Article] Narcolepsy as an initial manifestation of neuromyelitis optica with anti-aquaporin-4 antibody. (2009)
  • Author(s): Baba T, Nakashima I, Kanbayashi T, Konno M, Takahashi T, Fujihara K, Misu T, et al.
  • Journal Title: J Neurol 256 Pages: 287-288
  • Peer Reviewed
• [Journal Article] Procalcitonin might help in discrimination between meningeal neuro-Behqet disease and bacterial meningitis. (2009)
  • Author(s): Suzuki N, Mizuno H, Nezu M, Takai Y, Misu T, et al.
  • Journal Title: Neurology 72 Pages: 762-763
  • Peer Reviewed
• [Journal Article] CCR7+ myeloid dendritic cells together with CCR7+ T cells and CCR7+ macrophages invade CCL19+ nonnecrotic muscle fibers in inclusion body myositis. (2009)
  • Author(s): Tateyama M, Fujihara K, Misu T, et al.
  • Journal Title: J Neurol Sci 279 Pages: 47-52
  • Peer Reviewed
• [Journal Article] Pathology of Neuromyelitis optica (2009)
  • Author(s): 三須建郎
  • Journal Title: 臨床神経学 第49巻11号 Pages: 896-899
  • NAID: 10026291060
• [Journal Article] 【多発性硬化症・視神経脊髄炎と抗アクアポリン4抗体】視神経脊髄炎の病理学的特徴 (2009)
  • Author(s): 三須建郎, 藤原一男, 糸山泰人
  • Journal Title: あたらしい眼科 26巻10号 Pages: 1307-1314
• [Journal Article] 【多発性硬化症・視神経脊髄炎と抗アクアポリン4抗体】視神経脊髄炎の治療法 最新のエビデンスを元に (2009)
  • Author(s): 西山修平、三須建郎、中島一郎、高橋利幸、中村正史、佐藤滋、藤原一男、糸山泰人
  • Journal Title: あたらしい眼科 26巻10号 Pages: 1323-1327
• [Journal Article] 【多発性硬化症 病態解明と治療戦略の最前線(NMOを含めて)】多発性硬化症の病態と治療 多発性硬化症の神経病理 (2009)
  • Author(s): 三須建郎, 藤原一男, 糸山泰人
  • Journal Title: カレントテラピー 27巻9号 Pages: 759-763
• [Journal Article] 視神経脊髄炎とアストロサイトパチー 髄液中GFAPの有用性 (2009)
  • Author(s): 三須建郎
  • Journal Title: 東北医学雑誌 121巻1号 Pages: 101-103
  • NAID: 10026082991
• [Journal Article] 臨床医のための神経病理 (2009)
  • Author(s): 三須建郎, 藤原一男, 糸山泰人
  • Journal Title: NMO (Neuromyelitis optica) Clinical Neuroscience 27巻6号 Pages: 602-603
• [Journal Article] Neuromyelitis optica : pathogenicity of patient immunoglobulin in vivo (2009)
  • Author(s): Bradl M, Misu T, et al.
  • Journal Title: Annals of Neurology 66 Pages: 630-643
  • Peer Reviewed
• [Journal Article] A case of NMO seropositive for aquaporin-4 antibody more than 10 years before onset (2009)
  • Author(s): Nishiyama S, Ito T, Misu T, et al.
  • Journal Title: Neurology 72 Pages: 1960-1961
  • Peer Reviewed
• [Journal Article] Dorsal-roots enhancement and Wallerian degeneration of dorsal cord in the patient of acute sensory ataxic neuropathy (2009)
  • Author(s): Endo K, Suzuki N, Misu T, et al.
  • Journal Title: Journal of Neurology 256 Pages: 1765-1766
  • Peer Reviewed
• [Journal Article] Occurrence of acute large and edematous callosal lesions in neuromyelitis optica (2009)
  • Author(s): Nakamura M, Misu T, et al.
  • Journal Title: Multiple Sclerosis 15 Pages: 695-700
  • Peer Reviewed
• [Journal Article] Marked increase in cerebrospinal fluid glial fibrillary acidic protein in neuromyelitis optica : an astrocytic damage marker (2009)
  • Author(s): Misu T, Takano R, et al.
  • Journal Title: Journal of Neurology Neurosurgery and Psychiatry 80 Pages: 575-577
  • Peer Reviewed
• [Journal Article] Narcolepsy as an initial manifestation of neuromyelitis optica with anti-aquaporin-4 antibody (2009)
  • Author(s): Baba T, Nakashima I, et al
  • Journal Title: Journal of Neurology 256 Pages: 287-288
  • Peer Reviewed
• [Journal Article] Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thicvkenss in patients with neuromyelitis optica.
  • Author(s): Nakamura M, Nakazawa T, Doi H, Hariya T, Omodaka K, Misu T, et al.
  • Journal Title: Graefes Arch Clin Exp ophthalmol 2010, Epub ahead of print.
  • Peer Reviewed
• [Journal Article] Dorsal-roots enhancement and Wallerian degeneration of dorsal cord in the patient of acute sensory ataxic neuropathy.
  • Author(s): Endo K, Suzuki N, Misu T, et al.
  • Journal Title: J Neurol 2009, Epub ahead of print.
  • Peer Reviewed
• [Presentation] Pathogenesis of neuromyelitis optica : aquaporin 4 autoimmunity and astrocytopathy (2010)
  • Author(s): Misu T, et al
  • Organizer: 第51回 日本神経学会総会学術集会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-05-21
• [Presentation] Pathology of MS and NMO (2009)
  • Author(s): 三須建郎
  • Organizer: PACTRIMS 2009
  • Place of Presentation: 香港
  • Year and Date: 2009-11-21
• [Presentation] 視神経脊髄炎(NMO)と多発性硬化症の相違～アクアポリン4抗体の意義 (2009)
  • Author(s): 三須建郎
  • Organizer: 慶応ニューロサイエンス研究会2009
  • Place of Presentation: 慶応大学
  • Year and Date: 2009-10-31
• [Presentation] 視神経脊髄炎と多発性硬化症の相違～アクアポリン4抗体の意義 (2009)
  • Author(s): 三須建郎
  • Organizer: 慶応ニューロサイエンス研究会2009
  • Place of Presentation: 東京
  • Year and Date: 2009-10-31
• [Presentation] Aquaporin-4 Autoimmunity (2009)
  • Author(s): 三須建郎
  • Organizer: World Congress of Neurology(世界神経学会)
  • Place of Presentation: バンコク(タイ)
  • Year and Date: 2009-10-27
• [Presentation] Pathology of Neuromyelitis Optica (2009)
  • Author(s): 三須建郎
  • Organizer: International Symposium New Aspects of NMO
  • Place of Presentation: 淡路
  • Year and Date: 2009-10-03
• [Presentation] Pathology of Neuromyelitis Optica (2009)
  • Author(s): 三須建郎
  • Organizer: 第50回 日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2009-05-29
• [Presentation] Pathology of Neuromyelitis Optica. Symposium "NMO". (2009)
  • Author(s): Misu T.
  • Organizer: The 50^<th> Annual Meeting of the Japanese Society of Neurology
  • Place of Presentation: Sendai
  • Year and Date: 2009-05-22
• [Presentation] Spectrum of MS and NMO Part 1. From Pathological studies. (2009)
  • Author(s): Misu T.
  • Organizer: Pathology of MS and NMO. PACTRIMS 2009
  • Place of Presentation: Hong Kong
• [Presentation] Aquaporin-4 Autoimmunity. (2009)
  • Author(s): Misu T.
  • Organizer: 19^<th> World Congress of Neuology 2009
  • Place of Presentation: Bangkok Thailand
• [Presentation] Pathology of Neuromyelitis Optica. (2009)
  • Author(s): Misu T, Fujihara K, Takahashi H, et al.
  • Organizer: International Symposium New aspects of Neuromyelitis optica (NMO).
  • Place of Presentation: Awaji (Osaka)
• [Book] EBM 神経疾患の治療 2009-2010 (2010)
  • Author(s): 三須建郎, 他
  • Publisher: 中外医学社
• [Book] EBM神経疾患の治療 2009-2010 (2010)
  • Author(s): 三須建郎, 他
  • Publisher: 中外医学社
• [Remarks]
  • URL: http://www.ms.med.tohoku.ac.jp/index.html
• [Remarks]
  • URL: http://www.ms.med.tohoku.ac.jp/index.html