| Project/Area Number |
21790847
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KASAI Takashi Kyoto Prefectural University of Medicine, 医学研究科, 助教 (70516062)
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|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | α-シヌクレイン / オリゴマー / ニューロシン / パーキンソン病 / αシヌクレイン / アミロイド伝播 |
|---|
| Research Abstract |
We showed increased levels of extracelluar alpha-synuclein oligomer in CSF space of patients with Parkinson disease, which is supposed to play a role of amyloid propagation in alpha-synucleinopathy. We also demonstrated that Neurosin, a kind of serine proteases predominantly expressed in the central nervous system, secretes into extracelluar space and might play a role of extracelluar degradation of alpha-synuclein.
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