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Intranasal Administration of Autoantigenic Peptide /Poly (I:C) Enhanced protective efficacy to Diabetes induced by Alum-adjuvant Treatment in NOD Mice

Research Project

Project/Area Number 21790874
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionNagasaki University

Principal Investigator

NAKAMURA Kan  Nagasaki University, 病院, 医員 (70530426)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords1型糖尿病 / 粘膜免疫 / 抗原特異的免疫寛容療法
Research Abstract

Combination of single subQ-B:9-23/Alum and intranasal-B:9-23/Poly(I:C) less developed diabetes compared to the mice with single subQ-B:9-23/Alum alone or control mice up to 48 age-weeks (P<0.05).

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2010 2009 Other

All Presentation (12 results) Remarks (1 results)

  • [Presentation] Intranasal Administration of Autoantigenic Peptide/Poly (I:C) Enhanced Protective Efficacy to Diabetes Induced by Alum-adjuvant Treatment in NOD Mice2010

    • Author(s)
      中村寛
    • Organizer
      THE 11^<th> International Congress of the Immunology of Diabetes Society
    • Place of Presentation
      Songdo Convensia Icheon Korea
    • Year and Date
      2010-11-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] インスリンペプチドとPoly(I:C)経鼻投与による1型糖尿病進展阻止法の開発の試み2010

    • Author(s)
      中村寛
    • Organizer
      第8回1型糖尿病研究会
    • Place of Presentation
      長崎大学医学部良順会館
    • Year and Date
      2010-10-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] インスリンペプチドとpoly I : C投与による1型糖尿病発症阻止法の開発の試み2010

    • Author(s)
      中村寛
    • Organizer
      第24回日本糖尿病・肥満動物学会
    • Place of Presentation
      ホテルコスモスクエア国際交流センター
    • Year and Date
      2010-01-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] インスリンペプチドとpolyI:C投与による1型糖尿病発症阻止法の開発の試み2010

    • Author(s)
      中村寛
    • Organizer
      第8回1型糖尿病研究会
    • Place of Presentation
      長崎県(口頭発表)
    • Related Report
      2010 Final Research Report
  • [Presentation] インスリンペプチドとpolyI:C投与による1型糖尿病発症阻止法の開発の試み2010

    • Author(s)
      中村寛
    • Organizer
      第24回日本糖尿病・肥満動物学会年次学術総会
    • Place of Presentation
      大阪府(口頭発表)
    • Related Report
      2010 Final Research Report
  • [Presentation] インスリンペプチドとpoly I : C投与による1型糖尿病発症阻止法の開発の試み2009

    • Author(s)
      中村寛
    • Organizer
      第7回1型糖尿病研究会
    • Place of Presentation
      鬼怒川温泉『あさや』ホテル
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] NASAL ADMINISTRATION INSULIN B : 9-23 PEPTIDE WITH POLY (I : C) AFTER SINGLE SUBCUTANEOUS INJECTION PREVENTS DIAB WTES IN THE ELDER NOD MICE2009

    • Author(s)
      K Nakamura
    • Organizer
      THE 4th ASIAN CONGRESS ON AUTOIMMUNITY
    • Place of Presentation
      Suntec Singapore International Convertion & Exibition Centre
    • Year and Date
      2009-09-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] インスリンペプチドとpoly I : C投与による1型糖尿病発症阻止法の開発の試み2009

    • Author(s)
      中村寛
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      ホテルNCB
    • Year and Date
      2009-05-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] インスリンペプチドとpolyI:C投与による1型糖尿病発症阻止法の開発の試み2009

    • Author(s)
      中村寛
    • Organizer
      第7回1型糖尿病研究会
    • Place of Presentation
      栃木県(口頭発表)
    • Related Report
      2010 Final Research Report
  • [Presentation] Intranasal Administration of Autoantigenic Peptide/Poly(I:C)Enhanced Protective Efficacy to Diabetes Induced by Alum-adjuvant Treatment in NOD Mice2009

    • Author(s)
      中村寛
    • Organizer
      THE 11th International Congress of the Immunology of Diabetes Society
    • Place of Presentation
      韓国(仁川)(ポスター発表)
    • Related Report
      2010 Final Research Report
  • [Presentation] NASAL ADMINISTRATION OF INSULIN B:9-23 PEPTIDE WITH POLY(I:C)AFTER SINGLE SUBCUTASNEOUS INJECTION PREVENTS DIABETES IN ELDER NOD MICE2009

    • Author(s)
      中村寛
    • Organizer
      THE 4th ASIAN CONGRESS ON AUTOIMMUNITY
    • Place of Presentation
      Singapore(ポスター発表)
    • Related Report
      2010 Final Research Report
  • [Presentation] インスリンペプチドとpolyI:C投与による1型糖尿病発症阻止法の開発の試み2009

    • Author(s)
      中村寛
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪府(ポスター発表)
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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