Innovative Therapy for Diabetes : ・-cell Replacement and Preservation
Project/Area Number |
21790890
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Endocrinology
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Research Institution | Kyoto University |
Principal Investigator |
FUJIKURA Junji Kyoto University, 医学研究科, 助教 (70378743)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 糖尿病 / レプチン / 栄養学 / 移植・再生医療 / 再生医学 / 発生・分化 |
Research Abstract |
We crossmated leptin-overexpressing transgenic mice with Akita mice and examined therapeutic effects of leptin on insulin-deficient diabetes mellitus. Leptin has a therapeutic impact on the onset and progression of glucose intolerance, diabetic complications and longevity in a mouse model of insulin-deficient nonobese diabetes. These data suggest that leptin may be useful as a long-term therapeutic agent for treating human diabetes mellitus.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Podocyte-specific expression of tamoxifen-inducible Cre recombinase in mice.2010
Author(s)
Yokoi H, Kasahara M, Mukoyama M, Mori K, Kuwahara K, Fujikura J, Arai Y, Saito Y, Ogawa Y, Kuwabara T, Sugawara A, Nakao K.
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Journal Title
Nephrol Dial Transplant.,PubMed PMID : 20150167. 25(7)
Pages: 2120-2124
Related Report
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[Journal Article] Adipose tissue-specific regulation of angiotensinogen in obese humans and mice : impact of nutritional status and adipocyte hypertrophy.2010
Author(s)
Yasue S, Masuzaki H, Okada S, Ishii T, Kozuka C, Tanaka T, Fujikura J, Ebihara K, Hosoda K, Katsurada A, Ohashi N, Urushihara M, Kobori H, Morimoto N, Kawazoe T, Naitoh M, Okada M, Sakaue H, Suzuki S, Nakao K.
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Journal Title
Am J Hypertens.,PubMed PMID : 20057360 ; PubMed Central PMCID : PMC2842463. 23(4)
Pages: 425-431
Related Report
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[Journal Article] Adipose tissue-specific dysregulation of angiotensinogen by oxidative stress in obesity.2010
Author(s)
Okada S, Kozuka C, Masuzaki H, Yasue S, Ishii-Yonemoto T, Tanaka T, Yamamoto Y, Noguchi M, Kusakabe T, Tomita T, Fujikura J, Ebihara K, Hosoda K, Sakaue H, Kobori H, Ham M, Lee YS, Kim JB, Saito Y, Nakao K.
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Journal Title
Metabolism.,PubMed PMID : 20045538 ; PubMed Central PMCID : PMC2891233. 59(9)
Pages: 1241-1251
Related Report
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[Journal Article] Glucocorticoid reamplification within cells intensifies NF-kappaB and MAPK signaling and reinforces inflammation in activated preadipocytes.2010
Author(s)
Ishii-Yonemoto T, Masuzaki H, Yasue S, Okada S, Kozuka C, Tanaka T, Noguchi M, Tomita T, Fujikura J, Yamamoto Y, Ebihara K, Hosoda K, Nakao K.
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Journal Title
Am J Physiol Endocrinol Metab. Pub Med PMID : 19776225. 298(5),299(1)
Pages: 930-940
Related Report
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[Journal Article] Adipose tissue-specific dysregulation of angiotensinogen by oxidative stress in obesity.2010
Author(s)
Okada S, Kozuka C, Masuzaki H, Yasue S, Ishii-Yonemoto T, Tanaka T, Yamamoto Y, Noguchi M, Kusakabe T, Tomita T, Fujikura J, Ebihara K, Hosoda K, Sakaue H, Kobori H, Ham M, Lee YS, Kim JB, Saito Y, Nakao K.
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Journal Title
Metabolism.
Volume: 59
Pages: 1241-51
Related Report
Peer Reviewed
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[Journal Article] Podocyte-specific expression of tamoxifen-inducible Cre recombinase in mice.2010
Author(s)
Yokoi H, Kasahara M, Mukoyama M, Mori K, Kuwahara K, Fujikura J, Arai Y, Saito Y, Ogawa Y, Kuwabara T, Sugawara A, Nakao K.
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Journal Title
Nephrology Dialysis Transplantation.
Volume: 25
Pages: 2120-4
Related Report
Peer Reviewed
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[Journal Article] Glucocorticoid reamplification within cells intensifies NF{kappa}B and MAPK signaling and reinforces inflammation in activated preadipocytes.2010
Author(s)
Ishii-Yonemoto T, Masuzaki H, Yasue S, Okada S, Kozuka C, Tanaka T, Noguchi M, Tomita T, Fujikura J, Yamamoto Y, Ebihara K, Hosoda K, Nakao K.
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Journal Title
American Journal of Physiology Endocrinology and Metabolism.
Volume: 298
Related Report
Peer Reviewed
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[Journal Article] Podocyte-specific expression of tamoxifen-inducible Cre recombinase in mice.2010
Author(s)
Yokoi H, Kasahara M, Mukoyama M, Mori K, Kuwahara K, Fujikura J, Arai Y, Saito Y, Ogawa Y, Kuwabara T, Sugawara A, Nakao K.
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Journal Title
Nephrology Dialysis Transplantation. (in press)
Related Report
Peer Reviewed
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[Journal Article] Adipose tissue-specific regulation of angiotensinogen in obese humans and mice : impact of nutritional status and adipocyte hypertrophy.2010
Author(s)
Yasue S, Masuzaki H, Okada S, Ishii T, Kozuka C, Tanaka T, Fujikura J, Ebihara K, Hosoda K, Katsurada A, Ohashi N, Urushihara M, Kobori H, Morimoto N, Kawazoe T, Naitoh M, Okada M, Sakaue H, Suzuki S, Nakao K.
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Journal Title
American Journal of Hypertension. 4
Pages: 425-431
Related Report
Peer Reviewed
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[Journal Article] Adipose tissue-specific dysregulation of angiotensinogen by oxidative stress in obesity.2010
Author(s)
Okada S, Kozuka C, Masuzaki H, Yasue S, Ishii-Yonemoto T, Tanaka T, Yamamoto Y, Noguchi M, Kusakabe T, Tomita T, Fujikura J, Ebihara K, Hosoda K, Sakaue H, Kobori H, Ham M, Lee YS, Kim JB, Saito Y, Nakao K.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Glucocorticoid reamplification within cells intensifies NF{kappa}B and MAPK signaling and reinforces inflammation in activated preadipocytes.2010
Author(s)
Ishii-Yonemoto T, Masuzaki H, Yasue S, Okada S, Kozuka C, Tanaka T, Noguchi M, Tomita T, Fujikura J, Yamamoto Y, Ebihara K, Hosoda K, Nakao K.
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Journal Title
American Journal of Physiology Endocrinology and Metabolism. (in press)
Related Report
Peer Reviewed
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[Presentation] Leptin Transgenic Akita mouseを用いたインスリン分泌低下型糖尿病に対するレプチン治療2010
Author(s)
内藤雅喜, 藤倉純二, 海老原健, 宮永史子, 日下部徹, 宮本理人, 山本祐二, 野口倫生, 冨田努, 孫徹, 細田公則, 中尾一和
Organizer
第31回日本肥満学会
Place of Presentation
前橋テルサ
Year and Date
2010-10-01
Related Report
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[Presentation] インスリン分泌低下型糖尿病を来すAkitaマウスにおけるレプチンの治療効果の検討2010
Author(s)
内藤雅喜, 藤倉純二, 野口倫生, 冨田努, 森栄作, 小鳥真司, 日下部徹, 山本祐二, 宮本理人, 海老原健, 益崎裕章, 細田公則, 中尾一和
Organizer
第53回日本糖尿病学会
Place of Presentation
岡山市デジタルミュージアム
Year and Date
2010-05-29
Related Report
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[Presentation] Physiological roles of the Hes1 in the pancreas.2010
Author(s)
Junji Fujikura, Masaki Naito, Kiminori Hosoda, Hiroshi Iwakura, Tsutomu Tomita, Michio Noguchi, Shinji Odori, Eisaku Mori, Chisako Kozuka, Yuji Yamamoto, Ken Ebihara, Hiroaki Masuzaki, Yoshiya Kawaguchi, Rhoichiro Kageyama, Kazuwa Nakao
Organizer
14^<th> International Congress of Endocrinology
Place of Presentation
Kyoto International Conference Center
Year and Date
2010-03-28
Related Report
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[Presentation] Physiological roles of the Hes1 in the pancreas.2010
Author(s)
Fujikura, J, Naito, M, Hosoda, K, Iwakura, H, Tomita, T, Noguchi, M, Odori, S, Mori, E, Kozuka, C, Yamamoto, Y, Ebihara, K, Masuzaki, H, Kawaguchi, Y, Kageyama, R, Nakao, K
Organizer
14th International Congress of Endocrinology
Place of Presentation
京都国際会議場
Year and Date
2010-03-28
Related Report
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[Presentation] Leptin ameliorates hyperglycemia in diabetic, insulin-deficient non-obese Akita mice2010
Author(s)
Masaki Naito, Junji Fujikura, Kiminori Hosoda, Hiroshi Iwakura, Tsutomu Tomita, Michio Noguchi, Shinji Odori, Eisaku Mori, Toru Kusakabe, Yuji Yamamoto, Ken Ebihara, Hiroaki Masuzaki, Kazuwa Nakao
Organizer
14^<th> International Congress of Endocrinology
Place of Presentation
Kyoto International Conference Center
Year and Date
2010-03-27
Related Report
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[Presentation] Leptin ameliorates hyperglycemia in diabetic, insulin-deficient non-obese Akita mice.2010
Author(s)
Naito, M, Fujikura, J, Hosoda, K, Iwakura, H, Tomita, T, Noguchi, M, Odori, S, Mori, E, Kusakabe, T, Yamamoto, Y, Ebihara, K, Masuzaki, H, Nakao, K
Organizer
14th International Congress of Endocrinology
Place of Presentation
京都国際会議場
Year and Date
2010-03-27
Related Report
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[Presentation] Notch/Rbp-jシグナルと膵転写因子との相互作用2009
Author(s)
藤倉純二, 細田公則, 内藤雅喜, 森栄作, 小鳥真司, 野口倫生, 冨田努, 岩倉浩, 小塚智沙代, 岡田定規, 泰江慎太郎, 石井崇子, 宮本理人, 田中智洋, 日下部徹, 山本祐二, 平田雅一, 海老原健, 益崎裕章, 中尾一和
Organizer
第52回日本糖尿病学会年次学術集会
Place of Presentation
大阪国際会議場
Year and Date
2009-05-22
Related Report
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[Presentation] Notch/Rbp-jシグナルと膵転写因子との相互作用2009
Author(s)
藤倉純二, 細田公則, 内藤雅喜, 森栄作, 小鳥真司, 野口倫生, 冨田努, 岩倉浩, 小塚智沙代, 岡田定規, 泰江慎太郎, 石井崇子, 宮本理人, 田中智洋, 日下部徹, 山本祐二, 平田雅一, 海老原健, 益崎裕章, 中尾一和
Organizer
第82回日本内分泌学会学術総会
Place of Presentation
群馬県民会館
Year and Date
2009-04-23
Related Report
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