| Project/Area Number |
21790940
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKAMURA Tomohisa The University of Tokyo, 医学部附属病院, 特任助教 (10528996)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 臨床免疫 / 制御性T細胞 / 自己免疫疾患 / IL-10 / LAG3 / Egr2 |
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| Research Abstract |
Regulatory T cells(Tregs)are engaged in the maintenance of immunological self-tolerance. IL-10 has an important role in maintaining the normal immune state. However, it is difficult to assess the in vivo physiological function of IL-10-secreting Tregs because of the lack of its specific markers. Recently, we reported that IL-10-secreting Tregs can be delineated as CD4^+CD25^-Foxp3^-Tcells that characteristically express lymphocyte activation gene-3(LAG-3).Moreover, this novel CD4^+CD25^-LAG3^+Tregs(LAG3 Tregs)express anergy associated transcription factor Egr2, which confers Blimp-1, IL-10 and LAG3 expression of CD4^+Tcells. In this study, we confirmed the factors controlling LAG3 Treg-induction in an antigen specific manner. These findings could lead to the novel antigen-specific therapy for autoimmune diseases.
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