| Project/Area Number |
21790945
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
膠原病・アレルギー・感染症内科学
|
|---|
| Research Institution | Tohoku Institute of Technology |
|---|
Principal Investigator |
SAKAMOTO Yuzuru Tohoku Institute of Technology, 共通教育センター, 准教授 (30316434)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 好塩基球 / PIR-B / IL-3 / ITIM / Th2免疫応答 |
|---|
| Research Abstract |
To examine the potential involvement of PIR-B, the inhibitory type murine paired immunoglobulin-like receptor, in the regulation of Th2-type cytokine production in basophils, we used retroviral gene transfer system and analyzed PIR-B-deficient mice bone marrow-derived basophils. As a result, we found that PIR-B regulates IL-3-induced IL-4 production in murine basophils. Moreover, from the result of analysis that used various PIR-B mutants, PIR-B expressed on basophils negatively regulates IL-3-induced IL-4 production in an ITIM-independent manner, pointing to previously unrecognized regulatory mechanisms by PIR-B.
|
