Aberrant expression of LMO2 gene in T-ALL

• Project/Area Number: 21790975
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: University of Yamanashi
• Principal Investigator: HIROSE Kinuko University of Yamanashi, 大学院・医学工学総合研究部, 医学研究員 (70436880)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: LMO2 / T細胞性急性白血病 / 転写因子 / T細胞性リンパ性白血病

Research Abstract

The LMO2 gene was abberantly expressed in some B-precursor ALL cell lines. So we analyzed the LMO2 gene expression level during B-cell development. The LMO2 gene expression was high in CD34+/CD19- population of cord blood MNCs, and it was markedly down-regulated in the CD34+/CD19+ population. Gene silencing of LMO2 by siRNA induced apoptotic cell death. Abberant expression of LMO2 gene in B-precursor ALL promotes cell survival of immature lymphocytes and contributes to leukemogenesis.

Research Products

• [Journal Article] Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19). (2010)
  • Author(s): Hirose K, Inukai T, Kikuchi J, et al.
  • Journal Title: Blood. 116 Pages: 962-970
  • Peer Reviewed
• [Journal Article] Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17 ; 19) (2010)
  • Author(s): Kinuko Hirose
  • Journal Title: Blood Volume: 116 Pages: 962-970
  • Peer Reviewed
• [Presentation] 犬飼岳史B前駆細胞型ALLにおけるLMO2の過剰発現 (2010)
  • Author(s): 廣瀬衣子
  • Organizer: 日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-09-25
• [Presentation] B前駆細胞型ALLにおけるLMO2の過剰発現 (2010)
  • Author(s): 廣瀬衣子
  • Organizer: 日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-09-25
• [Remarks] ホームページ等
  • URL: http://www.med.yamanashi.ac.jp/clinical/pediatr/fpe/fpe101110h.html
• [Remarks]
  • URL: http://www.med.yamanashi.ac.jp/clinical/pediatr/fpe/fpe101110h.html