Aberrant expression of LMO2 gene in T-ALL
| Project/Area Number |
21790975
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
HIROSE Kinuko University of Yamanashi, 大学院・医学工学総合研究部, 医学研究員 (70436880)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | LMO2 / T細胞性急性白血病 / 転写因子 / T細胞性リンパ性白血病 |
|---|
| Research Abstract |
The LMO2 gene was abberantly expressed in some B-precursor ALL cell lines. So we analyzed the LMO2 gene expression level during B-cell development. The LMO2 gene expression was high in CD34+/CD19- population of cord blood MNCs, and it was markedly down-regulated in the CD34+/CD19+ population. Gene silencing of LMO2 by siRNA induced apoptotic cell death. Abberant expression of LMO2 gene in B-precursor ALL promotes cell survival of immature lymphocytes and contributes to leukemogenesis.
|
Report
(3 results)
Research Products
(6 results)
