Developmental roles of the subventricular zone-specific gene in the mammalian brain.

• Project/Area Number: 21791009
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Keio University
• Principal Investigator: ARAMAKI Michihiko 慶應義塾大学, 医学部, 特任助教 (20338099)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 発生・分化 / 脳室下帯 / 多極性細胞 / microRNA / 大脳新皮質形成期

Research Abstract

Mammalian cerebral cortex consists of six layers. Neurons in each layer communicate with each other and develop the complex networks. Highly sophisticated neuronal networks are considered to be origins of higher-order brain function in humans. Mammalian subventricular zone (SVZ) includes progenitor cells which generate massive amount of neurons during the brain development. In this study, we examined the expression level of SVZ-specific gene in human and mouse brain and proposed the microRNA-mediated regulatory mechanism of SVZ-specific gene expression.