Mechanism of L-asparaginase-induced pancreatitis and its prophylaxis using octreotide
| Project/Area Number |
21791010
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Juntendo University |
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Principal Investigator |
SUZUKI Mitsuyoshi Juntendo University, 医学部, 助教 (90449059)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 薬剤性膵炎 / 急性白血病 / L-asparaginase |
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| Research Abstract |
We demonstrated that in patients receiving ASNase therapy, the serum trypsin and pancreatic secretory trypsin inhibitor levels are usually elevated due to subclinical pancreatitis induced by the treatment. Futher, the mechanism of ASNase-induced pancreatic injury may involve an imbalance of the protease-antiprotease, such as, α1-antitrypsin, α2-macroglobulin. The present result also suggested that ASNase treatment with octreotide appears useful in prevent this complication in recovering patients.
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Report
(3 results)
Research Products
(29 results)
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[Presentation] Scoring System for the Severity of Acute Pancreatitis in Children2009
Author(s)
Suzuki M, Minowa K, Baba Y, Aoyagi Y, Fujii T, Fujitake T, Kudo T, Ohtsuka Y, Shimizu T
Organizer
11th Congress of the Asian Pan-Pacific Society of Pediatric Gastroenterology, Hepatology and Nutrition
Place of Presentation
Seoul, Korea
Related Report
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