The regulation of voltage-gated ion channels expressed on neuronal dendrites in hypoxic-ischemic encephalopathy

• Project/Area Number: 21791040
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Keio University
• Principal Investigator: ARIMITSU Takeshi 慶應義塾大学, 医学部, 助教 (60383840)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 樹状突起 / 電位依存性チャネル / 神経細胞 / 小児科学 / 新生児医学

Research Abstract

Previous study demonstrates that excitotoxicity damages neuronsin hypoxic-ischemic encephalopathy. Present study suggests that changes in neuronal activity leads to coordinated changes in protein expression and surface expression of hyperpolarization-acti

Research Products

• [Journal Article] Hepatocyte growth factor levels of cord blood in healthy term newborns. (2012)
  • Author(s): Hokuto I, Matsuzaki Y, Miwa M, Arimitsu T, Okishio E, Ikeda K
  • Journal Title: Arch Dis Child Fetal Neonatal Ed Volume: 97 Issue: 5 Pages: 732-3
  • DOI: 10.1111/j.1442-200x.2012.03698.x
  • Peer Reviewed
• [Journal Article] Functional hemispheric specialization in processing phonemic and prosodic auditory changes in neonates. (2011)
  • Author(s): Arimitsu T, Uchida-Ota M, Yagihashi T, Kojima S, Watanabe S, Hokuto I, Ikeda K, Takahashi T, Minagawa-Kawai Y
  • Journal Title: Front Psychol Volume: 2 Pages: 202-202
  • Peer Reviewed
• [Journal Article] Functional hemispheric specialization in processing phonemic and prosodic auditory changes in neonates (2011)
  • Author(s): Arimitsu T, et al
  • Journal Title: Frontiers in Psychology Volume: 2
  • Peer Reviewed
• [Journal Article] Activity-dependent regulation of HCN1 protein in cortical neurons (2009)
  • Author(s): Arimitsu T, Nuriya M, Ikeda K, Takahashi T, Yasui M
  • Journal Title: Biochem Biophys Res Commun Volume: 387 Issue: 1 Pages: 87-91
  • DOI: 10.1016/j.bbrc.2009.06.127
  • Peer Reviewed
• [Journal Article] Activity-dependent regulation of HCN1 protein in cortical neurons. (2009)
  • Author(s): Takeshi Arimitsu
  • Journal Title: Biochemical and biophysical research communications 387 Pages: 87-91
  • Peer Reviewed
• [Presentation] 在胎週数による新生児の音声誘発脳反応の変化 (2011)
  • Author(s): 有光威志
  • Organizer: 第56回日本未熟児新生児学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-11-14
• [Presentation] 近赤外分光法による早産児の音声誘発脳反応 (2011)
  • Author(s): 有光威志
  • Organizer: 第47回日本周産期・新生児医学会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2011-07-11
• [Presentation] 近赤外分光法による新生児の音声誘発脳反応 (2010)
  • Author(s): 有光威志
  • Organizer: 日本未熟児新生児学会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2010-11-06
• [Presentation] 高次脳機能に関わるhyperpolarization-activated cyclic nucleotide-gated channel 1 タンパクの分子・細胞学的制御機構 (2009)
  • Author(s): 有光威志
  • Organizer: 日本未熟児新生児学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-11-30
• [Presentation] 高次脳機能に関わるhyperpolarization-activated cyclic nucleotide-gated channel 1タンパクの分子・細胞学的制御機構 (2009)
  • Author(s): 有光威志
  • Organizer: 日本未熟児新生児学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-11-30
• [Book] Preliminary report on differences in cerebral hemodynamic responses to mother's voice between preterm and term neonates. (2011)
  • Author(s): Uchida-Ota M, Arimitsu T et al.
  • Publisher: CARLS series of advanced study of logic and sensibility.
• [Book] 神経系 低体温療法の生理学・生化学 どのように新生児の脳を保護しているのか? (2011)
  • Author(s): 有光威志、武内俊樹、池田一成
  • Publisher: へるす出版
• [Book] Early cerebral bases of phonemic and prosodic cue decoding assessed with neonate NIRS (2010)
  • Author(s): Minagawa-Kawai Y, Arimitsu T et al.
  • Publisher: Keio University Press
• [Book] 早期産帝王切開による児の影響 (2010)
  • Author(s): 有光威志、池田一成
  • Publisher: 東京医学社