The role of SLAM family molecules in the pathogenesis of murine lupus

• Project/Area Number: 21791073
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Kyoto University (2010); Department of Clinical Research, National Hospital Organization Kyoto Medical Center (2009)
• Principal Investigator: KITOH Akihiko 京都大学, 医学研究科, 助教 (40508438)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 全身性エリテマトーデス / SLE / SLAM / 制御性T 細胞 / 制御性T細胞

Research Abstract

SLAM^<hi>CD4^+ T cell population was essential for the maintenance of immunologic self tolerance. Prevention of autoimmunity by SLAM^<hi>CD4^+ T cell population was mainly attributed to CD4^+Foxp3^+ regulatory T cells contained in the population.

Research Products

• [Journal Article] Perturbations of both nonregulatory and regulatory FOXP3+ T cells in patients with malignant melanoma (2011)
  • Author(s): Fujii H., Arakawa A., Kitoh A., Miyara M., Kato M., Kore-Eda S., Sakaguchi S., Miyachi Y., Tanioka M., and Ono M.
  • Journal Title: Br J Dermatol. Volume: 164 Issue: 5 Pages: 1052-1060
  • DOI: 10.1111/j.1365-2133.2010.10199.x
  • Peer Reviewed
• [Journal Article] 【ヘルペスウイルス感染症】<臨床例>動眼神経麻痺と外転神経麻痺をきたした眼部帯状疱疹 (2011)
  • Author(s): 楠葉展大、辻花光次郎、涌田あすか、鬼頭昭彦、十一英子
  • Journal Title: 皮膚病診療 Volume: 33 Pages: 1145-1145
• [Journal Article] 臨床的、組織学的にLangerhans 細胞組織球症を思わせた乳児疥癬の1例 (2011)
  • Author(s): 東前和奈、鬼頭昭彦、松村由美、是枝哲、宮地良樹
  • Journal Title: 日本小児皮膚科学会雑誌 Volume: 30 Pages: 41-44
  • NAID: 10027866906
• [Journal Article] 【小児の先天性皮膚疾患】臨床例レーザー治療の奏効した色素血管母斑症IIa型 (2011)
  • Author(s): 趙玲愛, 鬼頭昭彦, 野村安隆, 中西新, 中村陽子, 宮地良樹, 宇谷厚志
  • Journal Title: 皮膚病診療 Volume: 33 Pages: 125-128
• [Journal Article] Perturbations of both nonregulatory and regulatory FOXP3+T cells in patients with malignant melanoma (2011)
  • Author(s): Fujii H., Arakawa A., Kitoh A., Miyara M., Kato M., Kore-Eda S., Sakaguchi S., Miyachi Y., Tanioka M., Ono M
  • Journal Title: Br J Dermatol Volume: 164 Pages: 1052-1060
  • Peer Reviewed
• [Journal Article] Pemphigoid without mucosal involvement showing autoantibodies against laminin-332 gamma2 subunit (2010)
  • Author(s): Endo Y., Kato M., Kitoh A., Kore-Eda S., Fukuda S., Hashimoto T., Toda K., Miyachi Y., and Utani A.
  • Journal Title: Br J Dermatol Volume: 163 Issue: 5 Pages: 1120-1122
  • DOI: 10.1111/j.1365-2133.2010.09922.x
  • Peer Reviewed
• [Journal Article] Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor (2009)
  • Author(s): Miyara M., Yoshioka Y., Kitoh A., Shima T., Wing K., Niwa A., Parizot C., Taflin C., Heike T., Valeyre D., Mathian A., Nakahata T., Yamaguchi T., Nomura T., Ono M., Amoura Z., Gorochov G., and Sakaguchi S.
  • Journal Title: Immunity Volume: 30 Issue: 6 Pages: 899-911
  • DOI: 10.1016/j.immuni.2009.03.019
  • Peer Reviewed
• [Journal Article] Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells (2009)
  • Author(s): Kitoh A., Ono M., Naoe Y., Ohkura N., Yamaguchi T., Yaguchi H., Kitabayashi I., Tsukada T., Nomura T., Miyachi Y., Taniuchi I., and Sakaguchi S.
  • Journal Title: Immunity Volume: 31 Issue: 4 Pages: 609-620
  • DOI: 10.1016/j.immuni.2009.09.003
  • Peer Reviewed
• [Presentation] Analysis of the mechanism underlying contact hypersensitivity-induced hair growth (2011)
  • Author(s): Kitoh A., et al
  • Organizer: Annual Meeting of JSID
  • Place of Presentation: 京都
  • Year and Date: 2011-12-10
• [Presentation] Analysis of the mechanism underlying contact hypersensitivity-induced hair growth (2011)
  • Author(s): Kitoh A., Nakamizo S., Miyachi Y., and Kabashima K.
  • Organizer: 第36回日本研究皮膚科学会総会
  • Place of Presentation: 京都