Aire-mediated mechanism of tolerance against Dsg3, the autoantigen in pemphigus vulgaris
Project/Area Number |
21791093
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Dermatology
|
Research Institution | Keio University |
Principal Investigator |
WADA Naoko Keio University, 医学部, 研究員(非常勤) (50306776)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | Aire / 天疱瘡 / 免疫寛容 / 胸腺 |
Research Abstract |
The transcription factor Aire promotes the expression of a wide range of peripheral organ-specific antigens in the thymus, which will serve as self-antigens in negative selection. We demonstrated desmoglein 3 (Dsg3), the autoantigen in pemphigus vulgaris, expressed in mouse thymus dependent on Aire. Aire^<-/-> T cells, but not Aire^<+/+> T cells, induced low levels of anti-Dsg3 IgG production when transferred with Dsg3^<-/-> B cells in Rag2^<-/-> recipient mice. These findings suggest that Aire plays a role in tolerance against Dsg3 through the selection of T cells in thymus.
|
Report
(3 results)
Research Products
(3 results)
-
[Journal Article] Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T-cell tolerance.2011
Author(s)
Naoko Wada, Koji Nishifuji, Taketo Yamada, Jun Kudoh, Nobuyoshi Shimizu, Mitsuru Matsumoto, Leena Peltonen, Seiho Nagafuchi, Masayuki Amagai
-
Journal Title
Journal of Investigative Dermatology 131
Pages: 410-417
Related Report
Peer Reviewed
-
-