Identification of suicidal-behavior related genes in the HPA axis regulating stress response
| Project/Area Number |
21791132
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Kobe University |
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Principal Investigator |
HISHIMOTO Akitoyo Kobe University, 大学院・医学研究科, 講師 (50529526)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 臨床精神分子遺伝学 / 自殺 / FKBP5 / NOS1 / 統合失調症 / 死後脳 / polymorphism / アレキシサイミア / 性差 / TPH1 / TPH2 / ALDH2 / ADH1B / RGS2 |
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| Research Abstract |
We explored a positive association of suicidal behavior with certain haplotypes of FKBP5 gene which regulates the hypothalamo-pituitary-adrenal axis in stress response. We additionally explored associations of suicidal behavior with polymorphisms of ALDH2 and NOS1 genes. We also found a positive association of schizophrenia with polymorphisms of NOS1 gene. Our findings suggest that suicidal behavior is involved in the genetic vulnerability and that certain polymorphisms might be useful for a biomarker of suicidal behavior.
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Report
(3 results)
Research Products
(51 results)
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[Journal Article] Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression, and regulation by cannabinoid receptor ligands.2009
Author(s)
Qing-Rong Liu, Chun-Hung Pan, Akitoyo Hishimoto, Chuan-Yun Li, Zheng-Xiong Xi, Alvaro Llorente-Berzal, Maria-Paz Viveros, Hiroki Ishiguro, Tadao Arinami, Emmanuel Shan Onaivi, George R.Uhl.
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Journal Title
Genes, Brain and Behavior 8(5)
Pages: 512-530
Related Report
Peer Reviewed
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