Development of Novel Neovascularization-Imaging Agent for PET.

• Project/Area Number: 21791163
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: AITA Kazuki Hokkaido University, アイソトープ総合センター, 助教 (80456839)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 造影剤 / PET / 標識化 / Thymidine Phosphorylase / PET用放射性薬剤 / 放射性フッ素標識 / 腫瘍 / 悪性度診断

Research Abstract

The aim of this study is "Development of Novel PET(Positron Emission Tomography) Imaging Agent for Neovascularization". And we selected thymidine phosphorilase (TP) as the neovascularization indicator. So, we designed F-TPI as the novel neovascularization-imaging agent for PET. F-TPI has urasil structure and (radio) fluorine atom. And we succeeded in the synthesis of the precursor of F-TPI.