Basic Study on Stereotactic Body Radiation Therapy for Centrally Located Lung Cancer

• Project/Area Number: 21791188
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: MATSUO Yukinori Kyoto University, 医学研究科, 助教 (80456897)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 体幹部定位放射線治療 / 肺癌 / 癌 / 放射線 / 定位放射線治療

Research Abstract

Stereotactic body radiation therapy (SBRT) is an important treatment option for inoperable patients with early-stage lung cancer. Application of SBRT for centrally located lung cancer was limited. I conducted basic studies on SBRT for central tumors. Following issues were evaluated : dose-response relationship in local control, tumor motion during the treatment, differences between dose-calculation algorithms, and accuracies of body fixation in SBRT for the lung. After that, I played a role in making a multi-institutional trial of SBRT for central tumor.

Research Products

• [Journal Article] Prognostic factors in stereotactic body radiotherapy for non-small-cell lung cancer. (2011)
  • Author(s): Matsuo Y, Shibuya K, Nagata Y, Takayama K, Norihisa Y, Mizowaki T, Narabayashi M, Sakanaka K, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys. 79 Pages: 1104-1111
  • Peer Reviewed
• [Journal Article] Prognostic factors in stereotactic body radiotherapy for non-small-cell lung cancer. (2011)
  • Author(s): Matsuo Y, Shibuya K, Nagata Y, Takayama K, Norihisa Y, Mizowaki T, Narabayashi M, Sakanaka K, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 79 Pages: 1104-11
  • Peer Reviewed
• [Journal Article] Positional reproducibility of pancreatic tumors under end-exhalation breath-hold conditions using a visual feedback technique. (2011)
  • Author(s): Nakamura M, Shibuya K, Shiinoki T, Matsuo Y, Nakamura A, Nakata M, Sawada A, Mizowaki T, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: (In press)
  • Peer Reviewed
• [Journal Article] Characterization of FDG-PET images after stereotactic body radiation therapy for lung cancer. (2010)
  • Author(s): Matsuo Y, Nakamoto Y, Nagata Y, Shibuya K, Takayama K, Norihisa Y, Narabayashi M, Mizowaki T, Saga T, Higashi T, Togashi K, Hiraoka M.
  • Journal Title: Radiother Oncol. 97 Pages: 200-204
  • NAID: 120002674607
  • Peer Reviewed
• [Journal Article] Salvage lung resection for non-small cell lung cancer after stereotactic body radiotherapy in initially operable patients. (2010)
  • Author(s): Chen F, Matsuo Y, Yoshizawa A, Sato T, Sakai H, Bando T, Okubo K, Shibuya K, Date H.
  • Journal Title: J Thorac Oncol. 5 Pages: 1999-2002
  • Peer Reviewed
• [Journal Article] Stereotactic body radiation therapy for lung cancer: achievements and perspectives. (2010)
  • Author(s): Hiraoka M, Matsuo Y, Takayama K.
  • Journal Title: Jpn J Clin Oncol. 40 Pages: 846-854
• [Journal Article] Impact of multileaf collimator width on intraprostatic dose painting plans for dominant intraprostatic lesion of prostate cancer. (2010)
  • Author(s): Abe E, Mizowaki T, Norihisa Y, Narita Y, Matsuo Y, Narabayashi M, Nagata Y, Hiraoka M.
  • Journal Title: J Appl Clin Med Phys. 11 Pages: 3193-3193
  • Peer Reviewed
• [Journal Article] Characterization of FDG-PET images after stereotactic body radiation therapy for lung cancer. (2010)
  • Author(s): Matsuo Y, Nakamoto Y, Nagata Y, Shibuya K, Takayama K, Norihisa Y, Narabayashi M, Mizowaki T, Saga T, Higashi T, Togashi K, Hiraoka M.
  • Journal Title: Radiother Oncol. Volume: 97 Pages: 200-4
  • NAID: 120002674607
  • Peer Reviewed
• [Journal Article] Salvage lung resection for non-small cell lung cancer after stereotactic body radiotherapy in initially operable patients. (2010)
  • Author(s): Chen F, Matsuo Y, Yoshizawa A, Sato T, Sakai H, Bando T, Okubo K, Shibuya K, Date H.
  • Journal Title: J Thorac Oncol. Volume: 5 Pages: 1999-2002
  • Peer Reviewed
• [Journal Article] Stereotactic body radiation therapy for lung cancer : achievements and perspectives. (2010)
  • Author(s): Hiraoka M, Matsuo Y, Takayama K.
  • Journal Title: Jpn J Clin Oncol. Volume: 40 Pages: 846-54
  • Peer Reviewed
• [Journal Article] Impact of multileaf collimator width on intraprostatic dose painting plans for dominant intraprostatic lesion of prostate cancer. (2010)
  • Author(s): Abe E, Mizowaki T, Norihisa Y, Narita Y, Matsuo Y, Narabayashi M, Nagata Y, Hiraoka M.
  • Journal Title: J Appl Clin Med Phys. Volume: 11 Pages: 3193-3193
  • Peer Reviewed
• [Journal Article] 京都大学におけるIMRT (2009)
  • Author(s): 松尾幸憲, 他
  • Journal Title: 臨床放射線 54 Pages: 590-595
• [Journal Article] Measurement of Interfraction Variations in Position and Size of Target Volumes in Stereotactic Body Radiotherapy for Lung Cancer. (2009)
  • Author(s): Matsugi K, Narita Y, Sawada A, Nakamura M, Miyabe Y, Matsuo Y, Narabayashi M, Norihisa Y, Mizowaki T, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys 75 Pages: 543-548
  • Peer Reviewed
• [Journal Article] Survey of Stereotactic Body Radiation Therapy in Japan by the Japan 3-D Conformal External Beam Radiotherapy Group. (2009)
  • Author(s): Nagata Y, Hiraoka M, Mizowaki T, Narita Y, Matsuo Y, Norihisa Y, Onishi H, Shirato H.
  • Journal Title: Int J Radiat Oncol Biol Phys. 75 Pages: 343-347
  • Peer Reviewed
• [Journal Article] Effect of Audio Coaching on Correlation of Abdominal Displacement With Lung Tumor Motion. (2009)
  • Author(s): Nakamura M, Narita Y, Matsuo Y, Narabayashi M, Nakata M, Sawada A, Mizowaki T, Nagata Y, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys 75 Pages: 558-563
  • Peer Reviewed
• [Journal Article] New algorithm to simulate organ movement and deformation for four-dimensional dose calculation based on a three-dimensional CT and fluoroscopy of the thorax. (2009)
  • Author(s): Miyabe Y, Narita Y, Mizowaki T, Matsuo Y, Takayama K, Takahashi K, Kaneko S, Kawada N, Maruhashi A, Hiraoka M.
  • Journal Title: Med Phys 36 Pages: 4328-4339
  • Peer Reviewed
• [Journal Article] Impact of motion velocity on four-dimensional target volumes: a phantom study. (2009)
  • Author(s): Nakamura M, Narita Y, Sawada A, Matsugi K, Nakata M, Matsuo Y, Mizowaki T, Hiraoka M.
  • Journal Title: Med Phys. 36 Pages: 1610-1617
  • Peer Reviewed
• [Journal Article] 京都大学におけるIMRT (2009)
  • Author(s): 松尾幸憲, 他
  • Journal Title: 臨床放射線 54巻 Pages: 590-595
• [Journal Article] Measurement of Interfraction Variations in Position and Size of Target Volumes in Stereotactic Body Radiotherapy for Lung Cancer (2009)
  • Author(s): Matsugi K, Narita Y, Sawada A, Nakamura M, Miyabe Y, Matsuo Y, Narabayashi M, Norihisa Y, Mizowaki T, Hiraoka M
  • Journal Title: Int J Radiat Oncol Biol Phys 75 Pages: 543-548
  • Peer Reviewed
• [Journal Article] Survey of Stereotactic Body Radiation Therapy in Japan by the Japan 3-D Conformal External Beam Radiotherapy Group (2009)
  • Author(s): Nagata Y, Hiraoka M, Mizowaki T, Narita Y, Matsuo Y, Norihisa Y, Onishi H, Shirato H
  • Journal Title: Int J Radiat Oncol Biol Phys 75 Pages: 343-347
  • Peer Reviewed
• [Journal Article] Effect of Audio Coaching on Correlation of Abdominal Displacement With Lung Tumor Motion (2009)
  • Author(s): Nakamura M, Narita Y, Matsuo Y, Narabayashi M, Nakata M, Sawada A, Mizowaki T, Nagata Y, Hiraoka M
  • Journal Title: Int J Radiat Oncol Biol Phys 75 Pages: 558-563
  • Peer Reviewed
• [Journal Article] New algorithm to simulate organ movement and deformation for four-dimensional dose calculation based on a three-dimensional CT and fluoroscopy of the thorax (2009)
  • Author(s): Miyabe Y, Narita Y, Mizowaki T, Matsuo Y, Takayama K, Takahashi K, Kaneko S, Kawada N, Maruhashi A, Hiraoka M
  • Journal Title: Med Phys 36 Pages: 4328-4339
  • Peer Reviewed
• [Journal Article] Impact of motion velocity on four-dimensional target volumes : a phantom study. (2009)
  • Author(s): Nakamura M, Narita Y, Sawada A, Matsugi K, Nakata M, Matsuo Y, Mizowaki T, Hiraoka M
  • Journal Title: Med Phys 36 Pages: 1610-1617
  • Peer Reviewed
• [Journal Article] Positional reproducibility of pancreatic tumors under end-exhalation breath-hold conditions using a visual feedback technique.
  • Author(s): Nakamura M, Shibuya K, Shiinoki T, Matsuo Y, Nakamura A, Nakata M, Sawada A, Mizowaki T, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys. (in press)
  • Peer Reviewed
• [Presentation] MHI-TM2000(Vero)を用いた動体追尾照射の実施に向けた取り組み (2011)
  • Author(s): 松尾幸憲
  • Organizer: 第23回日本高精度放射線外部照射研究会
  • Place of Presentation: 秋葉原コンベンションホール(東京)
• [Presentation] 肺定位放射線治療における線量計算アルゴリズムの肺線量指標への影響および放射線肺臓炎との関連に関する検討 (2010)
  • Author(s): 松尾幸憲
  • Organizer: 第21回日本高精度放射線外部照射研究会
  • Place of Presentation: くまもと県民交流館パレア
  • Year and Date: 2010-01-30
• [Presentation] Evaluation of Dose-Volume Metrics Associated with Local Recurrence after Stereotactic Body Radiation Therapy for Lung Cancer. (2010)
  • Author(s): Matsuo Y
  • Organizer: Chicago Multidisciplinary Symposium in Thoracic Oncology
  • Place of Presentation: Hilton Chicago(米国シカゴ)
• [Presentation] 肺癌定位放射線治療後の局所制御に関連する線量体積因子の検討 (2010)
  • Author(s): 松尾幸憲
  • Organizer: 日本放射線腫瘍学会第23回学術大会
  • Place of Presentation: 東京ベイ舞浜ホテルクラブリゾート(浦安)
• [Presentation] 京都大学における肺定位放射線治療の高度化～放射線腫瘍医の立場から～ (2010)
  • Author(s): 松尾幸憲
  • Organizer: 日本放射線腫瘍学会第23回学術大会
  • Place of Presentation: 東京ベイ舞浜ホテルクラブリゾート(浦安)
• [Presentation] Analysis of Dose-volume Metrics Associated with Radiation Pneumonitis after Stereotactic Body Radiotherapy for Lung Cancer. (2010)
  • Author(s): Matsuo Y
  • Organizer: 52nd Annual Meeting of the American Society for Radiation Oncology
  • Place of Presentation: San Diego Convention Center (米国サンディエゴ)
• [Presentation] Stereotactic Body Radiotherapy for Non-Small Cell Lung Cancer: Kyoto University Experience. (2010)
  • Author(s): Matsuo Y
  • Organizer: 9th International Conference of the Asian Clinical Oncology Society
  • Place of Presentation: 岐阜グランドホテル(岐阜)
• [Presentation] Stereotactic Body Radiotherapy for Non-Small Cell Lung Cancer : Kyoto University Experience (2010)
  • Author(s): Matsuo Y
  • Organizer: the 9th International Conference of the Asian Clinical Oncology Society
  • Place of Presentation: 岐阜グランドホテル(岐阜)
• [Presentation] Analysis of Dose-volume Metrics Associated with Radiation Pneumonitis after Stereotactic Body Radiotherapy for Lung Cancer (2010)
  • Author(s): Matsuo Y.
  • Organizer: 52^<nd> Annual Meeting of the American Society for Radiation Oncology
  • Place of Presentation: San Diego Convention Center(米国サンディエゴ)
• [Presentation] Evaluation of Dose-Volume Metrics Associated with Local Recurrence after Stereotactic Body Radiation Therapy for Lung Cancer (2010)
  • Author(s): Matsuo Y.
  • Organizer: Chicago Multidisciplinary Symposium in Thoracic Oncology
  • Place of Presentation: Hilton Chicago(米国シカゴ)
• [Presentation] 肺定位放射線治療の適応と課題:T2腫瘍について (2009)
  • Author(s): 松尾幸憲
  • Organizer: 日本放射線腫瘍学会第22回学術大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-09-17
• [Presentation] 肺定位放射線治療の適応と課題:T2腫瘍について (2009)
  • Author(s): 松尾幸憲
  • Organizer: 日本放射線腫瘍学会 第22回学術大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-09-17
• [Presentation] 原発性肺癌に対する定位放射線治療における予後因子の検討 (2009)
  • Author(s): 松尾幸憲
  • Organizer: 第68回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-04-17
• [Presentation] Local Recurrence in Long-term Survivors after Stereotactic Body Radiation Therapy for Lung Cancer. (2009)
  • Author(s): Matsuo Y
  • Organizer: ASTRO's 51st Annual Meeting
  • Place of Presentation: シカゴ、米国
• [Presentation] Local Recurrence in Long-term Survivors after Stereotactic Body Radiation Therapy for Lung Cancer (2009)
  • Author(s): Yukinori Matsuo
  • Organizer: ASTRO's 51st Annual Meeting
  • Place of Presentation: シカゴ、米国
• [Book] State of the Art (2011)
  • Author(s): Matsuo Y, Shibuya K, Narabayashi M,Hiraoka M.Springer
  • Publisher: Shaped Beam Radiosurgery
• [Book] Shaped Beam Radiosurgery : State of the Art (2011)
  • Author(s): Matsuo Y, Shibuya K, Narabayashi M, Hiraoka M.
  • Publisher: Springer
• [Book] がん・放射線療法2010 (2010)
  • Author(s): 松尾幸憲
  • Publisher: 篠原出版新社