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Development of Computer-aided Classification System for early-onset Alzheimer' s Disease based on Three-dimensional Functional Magnetic Resonance Imaging

Research Project

Project/Area Number 21791199
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKyushu University

Principal Investigator

YAMASHITA Yasuo  九州大学, 大学病院, その他 (70380516)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords医用画像工学 / コンピュータ支援診断学 / アルツハイマー病 / 脳神経疾患 / 医療・福祉
Research Abstract

In recent years, various sorts of computer-aided diagnosis(CAD) system for Alzheimer' s disease(AD) patients have been developed to evaluate the degree of the atrophy in the cerebral cortex using morphological features in MR images. In this study, we developed a CAD system for AD patients based on functional imaging features derived from the cerebral blood flow maps measured by arterial spin labeling(ASL) technique which is one of magnetic resonance imaging(MRI) techniques. Our preliminary results suggest that the proposed method based on functional imaging features obtained by the ASL technique would be feasible for detection of patients with AD and would be expected using for a screening examination and a follow-up examination under treatment of AD.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (18 results)

All 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (12 results)

  • [Journal Article] MR脳血流マップ画像を用いたアルツハイマー病の鑑別支援システムの開発2011

    • Author(s)
      山下泰生, 有村秀孝, 吉浦敬, 徳永千晶, 桑水流純平, 馬込大貴, 門司晃, 小林幸次, 古閑省一, 中村泰彦, 大屋信義, 本田浩, 大喜雅文, 豊福不可依
    • Journal Title

      医用画像情報学会雑誌

      Volume: Vol.28, No.3 Pages: 72-78

    • NAID

      130001206625

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Computer-aided Classification of Patients with Alzheimer's Disease Based on Cerebral Blood Flow Map measured by Arterial Spin Labeling MRI2010

    • Author(s)
      Yamashita Y, Arimura H, Yoshiura T, et al.
    • Journal Title

      Computer Assisted Radiology and Surgery Proceedings

      Volume: Vol.5(S1)

    • Related Report
      2010 Annual Research Report
  • [Journal Article] ASLのCBFマップ画像を用いたアルツハイマー病の鑑別支援システムの開発2010

    • Author(s)
      山下泰生, 有村秀孝, 吉浦敬, 他
    • Journal Title

      信学技報

      Volume: MI2010-96 Pages: 100-104

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Computerized Classification of Patients with Alzheimer's Disease Based on Arterial Spin-Labeled perfusion MRI2010

    • Author(s)
      Yamashita Y, Arimura H, Yoshiura T, et al.
    • Journal Title

      World Automation Congress 2010 Proceedings

      Volume: (CD-R)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ASLによる脳血流マップに基づいたアルツハイマー型認知症の鑑別支援診断システムの開発2010

    • Author(s)
      山下泰生, 有村秀孝, 吉浦敬, 他
    • Journal Title

      信学技報IEICE Technical Report, MI MI2009-95

      Pages: 107-109

    • NAID

      110007866406

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Computer-aided classification of patients with demenda of Alzheime's type based on cerebral blood flow determined with arterial spin labeling technique2010

    • Author(s)
      Yamashita Y, Arimura H, Yoshiura T, et al.
    • Journal Title

      SPIE Proceedings Vol.7624

    • Related Report
      2009 Annual Research Report
  • [Presentation] Features of Arterial Spin Labeling Cerebral Blood Flow2011

    • Author(s)
      Yamashita Y
    • Organizer
      Radiological Society of North America 2011(RSNA)
    • Place of Presentation
      CHICAGO, IL
    • Year and Date
      2011-12-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Computer-aided Classification System for Alzheimer's Disease Based on Functional Image Features of Arterial Spin Labeling Cerebral Blood Flow2011

    • Author(s)
      Yamashita Y
    • Organizer
      Radiological Society of North America 2011
    • Place of Presentation
      CHICAGO, IL, USA
    • Year and Date
      2011-12-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] ASLの脳血流マップを用いたアルツハイマー型認知症の鑑別支援診断システムの開発2011

    • Author(s)
      山下泰生
    • Organizer
      医用画像情報学会
    • Place of Presentation
      徳島
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ASLによる機能的特徴量に基づいたアルツハイマー病鑑別支援システムの構築2011

    • Author(s)
      山下泰生
    • Organizer
      第67回日本放射線技術学会総会学術大会
    • Place of Presentation
      (Web開催)
    • Year and Date
      2011-05-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Computerized Classification of Patients with Alzheimer' s Disease Based on Arterial Spin-Labeled perfusion MRI2010

    • Author(s)
      Yamashita Y
    • Organizer
      World Automation Congress2010
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-09-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Computerized Classification of Patients with Alzheimer's Disease Basedon Arterial Spin-Labeled perfusion MRI2010

    • Author(s)
      Yamashita Y
    • Organizer
      World Automation Congress 2010 IFMIP
    • Place of Presentation
      国際会議場(神戸市)
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] ASLのCBFマップ画像を用いたアルツハイマー病の鑑別支援システムの開発2010

    • Author(s)
      山下泰生
    • Organizer
      第29回日本医用画像工学会
    • Place of Presentation
      東海大学(伊勢原市)
    • Year and Date
      2010-07-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Computer-aided Classification of Patients with Alzheimer' s Disease Based on Cerebral Blood Flow Map measured by Arterial Spin Labeling MRI2010

    • Author(s)
      Yamashita Y
    • Organizer
      MRI, Computer Assisted Radiology and Surgery
    • Place of Presentation
      Geneva
    • Year and Date
      2010-06-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Computer-aided Classification of Patients with Alzheimer's Disease Based on Cerebral Blood Flow Map measured by Arterial Spin Labeling MRI2010

    • Author(s)
      Yamashita Y
    • Organizer
      Computer Assisted Radiology and Surgery 2010
    • Place of Presentation
      ジュネーブ,スイス
    • Year and Date
      2010-06-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] ASLによるCBFマップに基づいたアルツハイマー病の鑑別支援システムの開発2010

    • Author(s)
      山下泰生
    • Organizer
      第66回日本放射線技術学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2010-04-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Computer-aided classification of patients with dementia of Alzheimer' s type based on cerebral blood flow determined with arterial spin labeling technique2010

    • Author(s)
      Yamashita Y
    • Organizer
      SPIE International Symposium Medical Imaging
    • Place of Presentation
      San Diego, FL
    • Year and Date
      2010-02-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Computer-aided classification of Patients with dementia of Alzheimer's type based on cerebral blood flow determined with arterial spin labeling technique2010

    • Author(s)
      Yamashita Y, Arimura H, Yoshiura T, et al.
    • Organizer
      SPIEInternational Symposium Medical Imaging, 2010
    • Place of Presentation
      San Diego, CA, USA.
    • Year and Date
      2010-02-18
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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