| Project/Area Number |
21791265
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Miyagi Cancer Center Research Institute |
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Principal Investigator |
TADA Hiroshi Miyagi Cancer Center Research Institute, 共同研究員 (50436127)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 酵素 / 蛋白質 / ユビキチン / 小胞輸送 / 乳がん / トリプルネガティブ / EMT / がん幹細胞 / Vps4 / ErbB3 / 誘導系 |
|---|
| Research Abstract |
Because breast cancer often affects relatively younger females,underlying mechanisms which control the malignant phenotype is of great significance. Inthis study, we investigated how breast cancers including the triple negative breast cancersare controlled by EMT, a phenomenon in which solid tumors change their shapes and startmigration. A breast cancer cell line in which ESCRT, a vesicular transport system that determines proteins lifetime, is abrogated, in vivo proliferation of tumors was attenuated. Cells with forced expression of either twist or snail, two key transcriptional factors which induce EMT, resulted in an increase in cancer stemness, as judged by side population and CD44+/CD24^<-/low>. These results suggest that ESCRT system and EMT may positively control the malignant phenotypes of breast cancers.
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