Basic research of incretins for pancreas development and pancreas cancer progression

• Project/Area Number: 21791283
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Kyoto University
• Principal Investigator: KOIZUMI Masayuki Kyoto University, 医学研究科, 助教 (90512351)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 膵発生 / 膵癌 / インクレチン / GIP / GLP-1 / GLP1

Research Abstract

Incretins are synthesized and released at enteroendocrine cells, and stimulate beta cells in pancreas to maintain blood glucose. Their distributions and functions were investigated by using three dimensional exvivo culturing systems of mouse pancreas. The role of incretins in pancreatic cancer development are remains to be elucidated.

Research Products

• [Journal Article] Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. (2011)
  • Author(s): Furuyama K, Kawaguchi Y, Akiyama H, Horiguchi M, Kodama S, Kuhara T, Hosokawa S, Elbahrawy A, Soeda T, Koizumi M, Masui T, Kawaguchi M, Takaori K, Doi R, Nishi E, Kakinoki R, Deng JM, Behringer RR, Nakamura T, Uemoto S.
  • Journal Title: Nat Genet. 43(1) Pages: 34-41
• [Journal Article] Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine (2011)
  • Author(s): Furuyama K, et al.
  • Journal Title: Nature Genetics Volume: 43 Pages: 34-41
  • Peer Reviewed
• [Presentation] 膵発生におけるGIP(Glucosedependent insulinotropic peptide)の発現とその機能
  • Organizer: 膵(基礎研究),ハイブリッドポスター,第109回日本外科学会定期学術集会HP-148-6